Amyloid-first and neurodegeneration-first profiles characterize incident amyloid PET positivity

• Published in: Neurology Vol. 81; no. 20; p. 1732
• Main Authors: Jack, Jr, Clifford R, Wiste, Heather J, Weigand, Stephen D, Knopman, David S, Lowe, Val, Vemuri, Prashanthi, Mielke, Michelle M, Jones, David T, Senjem, Matthew L, Gunter, Jeffrey L, Gregg, Brian E, Pankratz, Vernon S, Petersen, Ronald C
• Format: Journal Article
• Language: English
• Published: United States 12.11.2013
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - diagnosis; Alzheimer Disease - diagnostic imaging; Amyloid - metabolism; Brain - blood supply; Brain - diagnostic imaging; Brain - metabolism; Cognition Disorders - etiology; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Incidence; Magnetic Resonance Imaging; Male; Neurodegenerative Diseases - complications; Neurodegenerative Diseases - diagnostic imaging; Neurodegenerative Diseases - metabolism; Oxygen; Positron-Emission Tomography
• ISSN: 1526-632X
• DOI: 10.1212/01.wnl.0000435556.21319.e4

To estimate the incidence of and to characterize cognitive and imaging findings associated with incident amyloid PET positivity. Cognitively normal (CN) participants in the Mayo Clinic Study of Aging who had 2 or more serial imaging assessments, which included amyloid PET, FDG-PET, and MRI at each t...