Systemic lupus erythematosus presenting with generalized lymphadenopathy: a case report
Systemic lupus erythematosus (SLE) is an immune complex disease with many different clinical presentations. Here we report a 13-year-old female patient presenting with generalized lymphadenopathy, who meanwhile developed butterflly rash and pericarditis. The diagnosis of SLE was based on the clinica...
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Published in | Turkish journal of pediatrics Vol. 43; no. 1; pp. 94 - 96 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Turkey
Türk Pediatri Derneği
01.01.2001
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Abstract | Systemic lupus erythematosus (SLE) is an immune complex disease with many different clinical presentations. Here we report a 13-year-old female patient presenting with generalized lymphadenopathy, who meanwhile developed butterflly rash and pericarditis. The diagnosis of SLE was based on the clinical features, positive antinuclear antibody, and positive antibodies to dsDNA. The patient had an active disease and developed renal involvement, despite steroid therapy. The patient's clinical presentation, course and response to therapy are detailed, and the literature on lupus lymphadenitis is reviewed. |
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AbstractList | Systemic lupus erythematosus (SLE) is an immune complex disease with many different clinical presentations. Here we report a 13-year-old female patient presenting with generalized lymphadenopathy, who meanwhile developed butterflly rash and pericarditis. The diagnosis of SLE was based on the clinical features, positive antinuclear antibody, and positive antibodies to dsDNA. The patient had an active disease and developed renal involvement, despite steroid therapy. The patient's clinical presentation, course and response to therapy are detailed, and the literature on lupus lymphadenitis is reviewed. |
Author | Karasalihoğlu, S Vatansever, U Acunaş, B Biner, B |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11297170$$D View this record in MEDLINE/PubMed |
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References | 6. Schaller JG. Systemic lupus erythematosus (SLE). In: Behrman RE, Kliegman RM, Nelson WE, Vaughan VC (eds). Nelson Textbook of Pediatrics (14th ed). Philadelphia: W.B. Saunders Company; 1992: 624-627. 8. Efremidis A, Eisner AR, Grishman E, Rosenberg V. Hodgkin's Iymphoma in an adolescent with systemic lupus erythematosus. Cancer 1984; 53: 142-146. 17. Beaufils M, Koukİ F, Mignon F, et al. Clinical significance of anti-Sm antibodies in systemic lupus erythematosus. Am J Med 1983; 74: 201-205. 1. Lehman TJ. A practical guide to systemic lupus erythematosus. Pediatr CUn North Am 1995; 42:1223-1238. 13. Cassidy JT, Sullivan DB, Petty RE. Lupus nephritis and encephalopathy. Prognosis in 58 children. Arthritis Rheum 1977; 20 (Suppl): 351-354. 16. Barad FAJr, Andrews BS, Davids JS IV, et a!. Antibodies to Sm in patients with systemic lupus erythematosus. Correlation of Sm antibody titers with disease activity and other laboratory parameters. Arthritis Rheum 1981; 24: 1236-1244. 18. Shapira Y, Weinberger A, Wysenbeek AJ. Lymphadenopathy in systemic lupus erythematosus. Prevalence and relation to disease manifestations. Ciin Rheumatol 1996; 15: 335-338. 12. Chandrasekaran AN, Rajendran CP, Ramakriahnan S, Madhavan R, Parthİban M. Childhood systemic lupus erythematosus İn South India. Indian J Pediatr 1994; 61: 223-229. 2. Cassidy JT, Petty RE. Systemic lupus erythematosus. In: Cassidy JT, Petty RE (eds). Textbook of Pediatric Rheumatology (3rd ed). Philadelphia: W.B. Saunders Company; 1995: 260-232. 9. Eisner MD, AmoryJ, Mullaney B, Tierney LJr, Browner WS. Necrotizing lymphadenitis associated with systemic lupus erythematosus. Semin Arthritis Rheum 1996; 26: 477-482. 11. Gourley I, Beil AL, Biggart D. Kikuchi's disease as a presenting feature of mixed connective tissue disease. CUn Rheumatol 1995; 14: 104-107. 14. Al Attİa HM, George S. Characterization of systemic lupus erythematosus in patients in U.A.E. Clin Rheum 1995; 14: 171-176. 15. Delgado EA, Malieson PN, Pirie GE, Petty RE. The pulmonary manifestations of childhood onset systemic lupus erythematosus. Semin Arthritis Rheum 1990; 19: 285-293. 7. Lanzkowsky P. Manual of Pediatric Hematoiogy and Oncology (2nd ed). New York: Chruchill Livingstone Inc.; 1995: 273-277. 4. Tan EM, Cohen AS, Fries JF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25: 1271-1277. 3. Harley JB, Sestak AL, Willis LG, Fu SM, Hansen JA, Reichlin M. A model for disease heterogeneity in systemic lupus erythematosus. Arthritis Rheum 1989; 32: 826-836. 5. Jacobs JC. Systemic lupus erythematosus in childhood. Report of 35 cases, with discussion of seven apparently induced by anticonvulsant medication, and of prognosis and treatment. Pediatrics 1963; 32: 257-264. 10. Bhalla R, Ajmani HS, Kim WW, Swedier WI, Lazarevic MB, Skosey JL. Systemic lupus erythematosus and Hodgkin's Iymphoma. J Rheum 1993; 20: 1316-1320. |
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SubjectTerms | Adolescence Adolescent Case report Diagnosis, Differential Ergenlik Female Hemic and lymphatic diseases Hemik ve lenfatik hastalıklar Humans Lenfatik hastalıklar Lupus eritematozus, sistemik Lupus Erythematosus, Systemic Lupus Erythematosus, Systemic - complications Lupus Erythematosus, Systemic - diagnosis Lymphatic Diseases Lymphatic Diseases - complications Olgu sunumu Tanı, ayırıcı |
Title | Systemic lupus erythematosus presenting with generalized lymphadenopathy: a case report |
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