A role for peptide in determining MHC class II structure

• Published in: Nature (London) Vol. 353; no. 6340; pp. 167 - 170
• Main Authors: Sadegh-Nasseri, S, Germain, R N
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 12.09.1991
• Subjects: Animals; Antigens - metabolism; Cellular biology; Cytochromes - chemistry; Histocompatibility Antigens Class II - chemistry; Hydrogen-Ion Concentration; In Vitro Techniques; Ligands; Mice; Molecules; Muramidase - chemistry; Muramidase - immunology; Ovalbumin - chemistry; Ovalbumin - immunology; Peptides - physiology; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Proteins; Space life sciences

T lymphocytes recognize antigen-derived peptides associated with major histocompatibility complex (MHC) class I or class II proteins. Peptide is critical in class I heavy-chain folding and/or stable association with beta 2-microglobulin. Although data exist suggesting a relationship between class II...