Human Adipose-Derived Mesenchymal Stem Cells for Osseous Rehabilitation of Induced Osteoradionecrosis: A Rodent Model

• Published in: Otolaryngology-head and neck surgery Vol. 156; no. 4; p. 616
• Main Authors: Janus, Jeffrey R, Jackson, Ryan S, Lees, Katherine A, Voss, Stephen G, Wilson, Zachary C, Remmes, Nicholas B, Keeney, Michael G, Garcia, Joaquin J, San Marina, Serban
• Format: Journal Article
• Language: English
• Published: England 01.04.2017
• Subjects: Animals; Brachytherapy; Cell Count; Collagen; Combined Modality Therapy; Disease Models, Animal; Humans; Mandible - pathology; Mandible - radiation effects; Mandibular Diseases - pathology; Mandibular Diseases - therapy; Mesenchymal Stem Cell Transplantation; Osteoblasts; Osteoclasts; Osteoradionecrosis - pathology; Osteoradionecrosis - therapy; Platelet-Rich Plasma; Prospective Studies; Radiation Injuries, Experimental; Rats, Nude; mandible; translational research; osteoradionecrosis; animal model

Objective Human adipose-derived mesenchymal stem cells (ADSCs) were used to rehabilitate bone damaged by osteoradionecrosis (ORN) in an established animal model. Study Design Prospective animal study. Setting Academic department laboratory. Subjects and Methods After institutional review board and I...