Metabolic consequences of sepsis-induced acute lung injury revealed by plasma ¹H-nuclear magnetic resonance quantitative metabolomics and computational analysis

• Published in: American journal of physiology. Lung cellular and molecular physiology Vol. 300; no. 1; pp. L4 - L11
• Main Authors: Stringer, Kathleen A, Serkova, Natalie J, Karnovsky, Alla, Guire, Kenneth, Paine, 3rd, Robert, Standiford, Theodore J
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.01.2011
• Subjects: Acute Lung Injury - blood; Acute Lung Injury - pathology; Humans; Magnetic Resonance Spectroscopy - methods; Metabolomics - methods; Metabolomics - trends; Phenotype; Pilot Projects; Reference Values; Sepsis - blood; Sepsis - complications; Sepsis - genetics

Metabolomics is an emerging component of systems biology that may be a viable strategy for the identification and validation of physiologically relevant biomarkers. Nuclear magnetic resonance (NMR) spectroscopy allows for establishing quantitative data sets for multiple endogenous metabolites withou...