Maternal CD4+ and CD8+ T Cell Tolerance Towards a Fetal Minor Histocompatibility Antigen in T Cell Receptor Transgenic Mice

• Published in: Biology of reproduction Vol. 89; no. 4; p. 102
• Main Authors: PERCHELLET, Antoine L, JASTI, Susmita, PETROFF, Margaret G
• Format: Journal Article
• Language: English
• Published: Madison, WI Society for the Study of Reproduction 01.10.2013; Society for the Study of Reproduction, Inc
• Subjects: Animals; Biological and medical sciences; CD4-Positive T-Lymphocytes - immunology; CD4-Positive T-Lymphocytes - metabolism; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - metabolism; Cells, Cultured; Crosses, Genetic; Down-Regulation; Female; Fetal Resorption - immunology; Fetal Resorption - metabolism; Fundamental and applied biological sciences. Psychology; Histocompatibility, Maternal-Fetal; Immune Tolerance; Inducible T-Cell Co-Stimulator Protein - metabolism; Lymphopoiesis; Mice; Mice, Inbred C57BL; Mice, Transgenic; Minor Histocompatibility Antigens - chemistry; Minor Histocompatibility Antigens - metabolism; Pregnancy; Pregnancy Maintenance; Receptors, Antigen, T-Cell - genetics; Receptors, Antigen, T-Cell - metabolism; Specific Pathogen-Free Organisms; Spleen - cytology; Spleen - immunology; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Vertebrates: reproduction; T cell receptor; Rodentia; fetal antigen; Transgenic animal; Tolerance; MHC class I; MHC class II; T cells; Antigen; Pregnancy; Vertebrata; Reproduction; Mammalia; Mouse; T-Lymphocyte; Fetus; pregnancy

Tolerance of the maternal immune system in pregnancy is important for successful pregnancy because the semiallogeneic fetus may be subject to antifetal responses. We examined maternal tolerance to the fetus using a murine system in which a model paternally inherited antigen, ovalbumin (OVA), is expr...