[ super(11)C]UCB-A, a novel PET tracer for synaptic vesicle protein 2 A

• Published in: Nuclear medicine and biology Vol. 43; no. 6; pp. 325 - 332
• Main Authors: Estradaa, Sergio, Lubberinkb, Mark, Thibblinb, Alf, Sprychad, Margareta, Buchanane, Tim, Mestdaghe, Nathalie, Kendae, Benoit, Merciere, Joel, Provinse, Laurent, Gillarde, Michel, Tytgate, Dominique, Antonia, Gunnar
• Format: Journal Article
• Language: English
• Published: 01.06.2016
• Subjects: [C-11]UCB-A; Epilepsy; Preclinical PET; SV2A

Introduction: Development of a selective and specific high affinity PET tracer, [ super(11)C]UCB-A, for the in vivo study of SV2A expression in humans. Radiochemistry and preclinical studies in rats and pigs including development of a tracer kinetic model to determine V sub(T). A method for the meas...