Thiazolidinediones repress ob gene expression in rodents via activation of peroxisome proliferator-activated receptor gamma

• Published in: The Journal of clinical investigation Vol. 98; no. 4; pp. 1004 - 1009
• Main Authors: De Vos, P, Lefebvre, A M, Miller, S G, Guerre-Millo, M, Wong, K, Saladin, R, Hamann, L G, Staels, B, Briggs, M R, Auwerx, J
• Format: Journal Article
• Language: English
• Published: United States 15.08.1996
• Subjects: Adipocytes - metabolism; Adipose Tissue - anatomy & histology; Adipose Tissue - metabolism; Animals; Base Sequence; DNA Primers - chemistry; Enzyme Activation; Gene Expression - drug effects; Humans; Leptin; Liver - anatomy & histology; Molecular Sequence Data; Organ Size - drug effects; Promoter Regions, Genetic; Proteins - genetics; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear - agonists; Receptors, Cytoplasmic and Nuclear - metabolism; RNA, Messenger - genetics; Thiazoles - pharmacology; Thiazolidinediones; Transcription Factors - agonists; Transcription Factors - metabolism
• ISSN: 0021-9738
• DOI: 10.1172/JCI118860

The ob gene product, leptin, is a signaling factor regulating body weight and energy balance. ob gene expression in rodents is increased in obesity and is regulated by feeding patterns and hormones, such as insulin and glucocorticoids. In humans with gross obesity, ob mRNA levels are higher, but oth...