Transforming growth factor-β1 and cigarette smoke inhibit the ability of β2-agonists to enhance epithelial permeability

• Published in: American journal of respiratory cell and molecular biology Vol. 52; no. 1; pp. 65 - 74
• Main Authors: Unwalla, Hoshang J, Ivonnet, Pedro, Dennis, John S, Conner, Gregory E, Salathe, Matthias
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.01.2015
• Subjects: Adenylyl Cyclases - metabolism; Adrenergic beta-2 Receptor Agonists - pharmacology; Biological Transport, Active; Bronchi - metabolism; Bronchi - pathology; Cells, Cultured; Cyclic AMP - metabolism; Cyclic AMP-Dependent Protein Kinases - metabolism; Cystic Fibrosis Transmembrane Conductance Regulator - metabolism; Epithelial Cells - metabolism; Epithelial Cells - pathology; Humans; Original Research; Permeability; Receptors, Adrenergic, beta-2 - metabolism; Respiratory Mucosa - metabolism; Respiratory Mucosa - pathology; Signal Transduction; Smoking - adverse effects; Smoking - metabolism; Smoking - pathology; Transforming Growth Factor beta1 - metabolism; cystic fibrosis transmembrane conductance regulator; epithelial permeability; cigarette smoke; transforming growth factor-β

Chronic bronchitis, caused by cigarette smoke exposure, is characterized by mucus hypersecretion and reduced mucociliary clearance (MCC). Effective MCC depends, in part, on adequate airway surface liquid. Cystic fibrosis transmembrane conductance regulator (CFTR) provides the necessary osmotic gradi...