Chronic inhibition of cortex microsomal Mg2+/Ca2+ ATPase‐mediated Ca2+ uptake in the rat pilocarpine model following epileptogenesis

• Published in: Journal of neurochemistry Vol. 79; no. 2; pp. 319 - 327
• Main Authors: Parsons, J. Travis, Churn, Severn B., DeLorenzo, Robert J.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.10.2001; Blackwell
• Subjects: Biological and medical sciences; calcium homeostasis; endoplasmic reticulum; epilepsy; Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy; Medical sciences; Nervous system (semeiology, syndromes); Neurology; SERCA; SREDs; status epilepticus; Antiglaucomatous agent; Animal model; Nervous system diseases; Calcium; Rat; Epilepsy; Rodentia; Pilocarpine; Inorganic element; Cerebral disorder; Parasympathomimetic; Vertebrata; Chronic; Mammalia; Central nervous system disease; Endoplasmic reticulum

In the rat pilocarpine model, 1 h of status epilepticus caused significant inhibition of Mg2+/Ca2+ ATPase‐mediated Ca2+ uptake in cortex endoplasmic reticulum (microsomes) isolated immediately after the status episode. The rat pilocarpine model is also an established model of acquired epilepsy. Seve...