Knockdown of long non-coding RNA TUG1 depresses apoptosis of hippocampal neurons in Alzheimer’s disease by elevating microRNA-15a and repressing ROCK1 expression

• Published in: Inflammation research Vol. 69; no. 9; pp. 897 - 910
• Main Authors: Li, Xia, Sheng-Wu, Wang, Xi-Ling, LI, Feng-Yuan, Yu, Hai-Ming, Cong
• Format: Journal Article
• Language: English
• Published: New York Springer Nature B.V 01.09.2020
• Subjects: Alzheimer's disease; Animal memory; Animal models; Antioxidants; Apoptosis; Hippocampus; Kinases; Learning; MicroRNAs; miRNA; Neurodegenerative diseases; Neurons; Non-coding RNA; Oxidative stress; Protein kinase; Reporter gene; Ribonucleic acid; RNA; Spatial discrimination learning; Spatial memory; Taurine; Therapeutic applications; Ventricle; Ventricles (cerebral); β-Amyloid

ObjectiveMany studies have already suggested the role of long non-coding RNAs (lncRNAs) in Alzheimer’s disease (AD), but the functions of lncRNA Taurine Upregulated Gene 1 (TUG1) in AD have been scarcely discussed. This study aims to verify how TUG1 affects hippocampal neurons in AD through modulati...