Role of endothelin-1 and its receptors, ETA and ETB, in the survival of human vascular endothelial cells

• Published in: Canadian journal of physiology and pharmacology Vol. 95; no. 10; p. 1298
• Main Authors: Mikhail, Marianne, Vachon, Pierre H, D’Orléans-Juste, Pedro, Jacques, Danielle, Bkaily, Ghassan
• Format: Journal Article
• Language: English
• Published: Ottawa Canadian Science Publishing NRC Research Press 01.10.2017
• Subjects: Apoptosis; Endothelial cells; Endothelin 1; Endothelins; Endothelium; Pharmacology; Physiology; Vein & artery diseases; Canada

Our previous work showed the presence of endothelin-1 (ET-1) receptors, ETA and ETB, in human vascular endothelial cells (hVECs). In this study, we wanted to verify whether ET-1 plays a role in the survival of hVECs via the activation of its receptors ETA and (or) ETB (ETAR and ETBR, respectively)....