Evaluation of in vivoT cell kinetics: use of heavy isotope labelling in type 1 diabetes

• Published in: Clinical and experimental immunology Vol. 172; no. 3; pp. 363 - 374
• Main Authors: Bollyky, J B, Long, S A, Fitch, M, Bollyky, P L, Rieck, M, Rogers, R, Samuels, P L, Sanda, S, Buckner, J H, Hellerstein, M K, Greenbaum, C J
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.06.2013
• Subjects: Diabetes; Immune system; Lymphocytes; Mathematical models; T cell receptors

Summary CD4+ memory cell development is dependent upon T cell receptor (TCR) signal strength, antigen dose and the cytokine milieu, all of which are altered in type 1 diabetes (T1D). We hypothesized that CD4+ T cell turnover would be greater in type 1 diabetes subjects compared to controls. In vitro...