I2-catalyzed synthesis of 3-aminopyrrole with homopropargylic amines and nitrosoarenes

• Published in: Chemical communications (Cambridge, England) Vol. 60; no. 27; pp. 3701 - 3704
• Main Authors: Qin, Jiaze, Jiang, Shixuan, Luo, Xiaofeng, Wang, Tianqiang, Liu, Peihua, Yuan, Bingxiang, Yan, Rulong
• Format: Journal Article
• Language: English
• Published: CAMBRIDGE Royal Soc Chemistry 28.03.2024; Royal Society of Chemistry
• Subjects: Amines; Chemical synthesis; Chemistry; Chemistry, Multidisciplinary; Functional groups; Oxidizing agents; Physical Sciences; Reagents; Science & Technology; ALPHA-AMINATION; HETEROARENES; O BOND-CLEAVAGE; REDUCTIVE ACYLATION; PYRROLYLAMIDES; ONE-POT; DNA; C-H AMIDATION; ANDROGEN ANTAGONISTS; CATALYZED ELECTROPHILIC AMINATION

The synthesis of 3-aminopyrrole using the amination reagent nitrosoarenes and homopropargylic amines catalyzed by I2 through cyclization and amination has been developed. This protocol features excellent functional group tolerance and mild reaction conditions, yielding 3-aminopyrroles in moderate to...