Rhoa-dependent murine prostate cancer cell proliferation and apoptosis: Role of protein kinase cζ

• Published in: Cancer research (Chicago, Ill.) Vol. 62; no. 9; pp. 2630 - 2636
• Main Authors: GHOSH, Paramita M, BEDOLLA, Roble, MIKHAILOVA, Margharita, KREISBERG, Jeffrey I
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.05.2002
• Subjects: Biological and medical sciences; Cell cycle, cell proliferation; Cell physiology; Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes; Fundamental and applied biological sciences. Psychology; Molecular and cellular biology; Cell proliferation; Protein kinase C; Prostate disease; Transgenic animal; Esterases; Signal transduction; Established cell line; Mechanism of action; Male genital diseases; Tumor cell; Urinary system disease; Enzyme; Triphosphoric monoester hydrolases; Transferases; Rodentia; dGTPase; Malignant tumor; Gene expression; In vitro; Vertebrata; Mammalia; Mouse; Cell death; Animal; Hydrolases; Prostate; Apoptosis

We previously showed that RhoA played an important role in the proliferation of murine Weprostate cancer (TRAMP) cells (P. M. Ghosh et al., Oncogene, 18: 4120-4130, 1999). Untransfected TRAMP cells as well as those expressing constitutively active RhoA (Q63L) mutant protein (Q63L cells) were highly...