Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence

• Published in: The Journal of neuroscience Vol. 33; no. 7; pp. 2794 - 2806
• Main Authors: Meinhardt, Marcus W, Hansson, Anita C, Perreau-Lenz, Stephanie, Bauder-Wenz, Christina, Stählin, Oliver, Heilig, Markus, Harper, Clive, Drescher, Karla U, Spanagel, Rainer, Sommer, Wolfgang H
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 13.02.2013
• Subjects: Alcoholism - genetics; Alcoholism - physiopathology; Alcoholism - psychology; Animals; Behavior, Animal - physiology; Brain - pathology; Central Nervous System Depressants - pharmacology; Diagnostic and Statistical Manual of Mental Disorders; Down-Regulation - physiology; Drug-Seeking Behavior - physiology; Ethanol - pharmacology; Gene Expression; Genetic Vectors; Humans; Immunohistochemistry; In Situ Hybridization; Lentivirus - genetics; Limbic System - physiology; Male; Microarray Analysis; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Receptors, Metabotropic Glutamate - deficiency; Receptors, Metabotropic Glutamate - genetics; Receptors, Metabotropic Glutamate - physiology; RNA - biosynthesis; RNA - genetics; Substance Withdrawal Syndrome - psychology

A key deficit in alcohol dependence is disrupted prefrontal function leading to excessive alcohol seeking, but the molecular events underlying the emergence of addictive responses remain unknown. Here we show by convergent transcriptome analysis that the pyramidal neurons of the infralimbic cortex a...