Analysis of Ca2+ mediated signaling regulating Toxoplasma infectivity reveals complex relationships between key molecules

• Published in: Cellular microbiology Vol. 19; no. 4
• Main Authors: Stewart, Rebecca J., Whitehead, Lachlan, Nijagal, Brunda, Sleebs, Brad E., Lessene, Guillaume, McConville, Malcolm J., Rogers, Kelly L., Tonkin, Christopher J.
• Format: Journal Article
• Language: English
• Published: Oxford Hindawi Limited 01.04.2017
• Subjects: Biosensors; Calcium (intracellular); Calcium ions; Calcium signalling; Calcium-binding protein; Calmodulin; Cyclic GMP; Egress; Fluxes; Genetic code; Infectivity; Intracellular; Intracellular signalling; Kinases; Motility; Parasites; Pathogenesis; Protein kinase; Signal transduction; Signaling

Host cell invasion, exit and parasite dissemination is critical to the pathogenesis of apicomplexan parasites such as Toxoplasma gondii and Plasmodium spp. These processes are regulated by intracellular Ca2+ signaling although the temporal dynamics of Ca2+ fluxes and down‐stream second messenger pat...