Realistic Albumin Concentrations in Virtual Subjects Across A Spectrum of Renal Function to Account for Variability in Protein Binding Within PBPK Models

• Published in: The AAPS journal Vol. 27; no. 4; p. 82
• Main Authors: Hu, Yuming, Scotcher, Daniel
• Format: Journal Article
• Language: English
• Published: United States 26.04.2025
• Subjects: Adult; Aged; Female; Glomerular Filtration Rate; Humans; Kidney - metabolism; Kidney - physiopathology; Male; Middle Aged; Models, Biological; Obesity - surgery; Pharmaceutical Preparations - metabolism; Protein Binding; Serum Albumin, Human - metabolism; Albumin; PBPK; Renal impairment; Predictive model; Protein binding

Use of physiologically-based pharmacokinetic (PBPK) modelling for extrapolation to organ impairment populations requires successful prediction for physiological changes. For drugs bound to human serum albumin (HSA), prediction of albumin concentrations is crucial to predict population differences in...