Realistic Albumin Concentrations in Virtual Subjects Across A Spectrum of Renal Function to Account for Variability in Protein Binding Within PBPK Models - Hu, Yuming; Scotcher, Daniel (The AAPS journal, 2025)
Keywords: Adult; Aged; Female; Glomerular Filtration Rate; Humans; Kidney - metabolism; Kidney - physiopathology; Male; Middle Aged; Models, Biological; Obesity - surgery; Pharmaceutical Preparations - metabolism; Protein Binding; Serum Albumin, Human - metabolism; Albumin; PBPK; Renal impairment; Predictive model; Protein binding