Intravenous arketamine for treatment-resistant depression: open-label pilot study
We aimed to analyze the efficacy and safety of arketamine, the R (−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery–...
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| Published in | European archives of psychiatry and clinical neuroscience Vol. 271; no. 3; pp. 577 - 582 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.04.2021
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0940-1334 1433-8491 1433-8491 |
| DOI | 10.1007/s00406-020-01110-5 |
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| Abstract | We aimed to analyze the efficacy and safety of arketamine, the
R
(−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery–Åsberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6–27.0;
p
< 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed. |
|---|---|
| AbstractList | We aimed to analyze the efficacy and safety of arketamine, the R(-)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery-Åsberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6-27.0; p < 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed. We aimed to analyze the efficacy and safety of arketamine, the R(-)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery-Åsberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6-27.0; p < 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed.We aimed to analyze the efficacy and safety of arketamine, the R(-)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery-Åsberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6-27.0; p < 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed. We aimed to analyze the efficacy and safety of arketamine, the R (−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery–Åsberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6–27.0; p < 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed. We aimed to analyze the efficacy and safety of arketamine, the R(−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label pilot trial, seven subjects with TRD received a single intravenous infusion of arketamine (0.5 mg/kg); primary outcome was change in Montgomery–Åsberg Depression Rating Scale (MADRS) 24 h after. Mean MADRS dropped from 30.7 before infusion to 10.4 after one day, a mean difference of 20.3 points [CI 95% 13.6–27.0; p < 0.001]; dissociation was nearly absent. Arketamine might produce fast-onset and sustained antidepressant effects in humans with favorable safety profile, like previously reported with animals; further controlled-trials are needed. |
| Author | Lima, Cassio S. Quarantini, Lucas C. Marques, Breno L. S. Guerreiro-Costa, Lívia N. F. Sanacora, Gerard Sampaio, Aline S. Mello, Rodrigo P. Caliman-Fontes, Ana Teresa Dias-Neto, Alberto L. Lacerda, Acioly L. T. Telles, Manuela Bezerra, Marília L. O. Loo, Colleen Silva, Samantha S. Bandeira, Igor D. Leal, Gustavo C. Correia-Melo, Fernanda S. Jesus-Nunes, Ana Paula Marback, Roberta F. Turecki, Gustavo Vieira, Flavia |
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O. organization: Laboratório de Neuropsicofarmacologia, Universidade Federal da Bahia, Laboratório de Pesquisa Em Neuropsicologia Clínica e Cognitiva, Universidade Federal da Bahia – sequence: 14 givenname: Alberto L. surname: Dias-Neto fullname: Dias-Neto, Alberto L. organization: Laboratório de Neuropsicofarmacologia, Universidade Federal da Bahia – sequence: 15 givenname: Samantha S. surname: Silva fullname: Silva, Samantha S. organization: Laboratório de Neuropsicofarmacologia, Universidade Federal da Bahia – sequence: 16 givenname: Aline S. surname: Sampaio fullname: Sampaio, Aline S. organization: Laboratório de Neuropsicofarmacologia, Universidade Federal da Bahia, Programa de Pós-Graduação Em Medicina e Saúde, Faculdade de Medicina da Bahia, Universidade Federal da Bahia, Departamento de Neurociências e Saúde Mental, Faculdade de Medicina da Bahia, Universidade Federal da Bahia – sequence: 17 givenname: Gerard surname: Sanacora fullname: Sanacora, Gerard organization: Department of Psychiatry, Yale University School of Medicine – sequence: 18 givenname: Gustavo surname: Turecki fullname: Turecki, Gustavo organization: McGill Group for Suicide Studies, Department of Psychiatry, Douglas Mental Health University Institute and McGill University – sequence: 19 givenname: Colleen surname: Loo fullname: Loo, Colleen organization: School of Psychiatry, University of New South Wales and Black Dog Institute – sequence: 20 givenname: Acioly L. 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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32078034$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.2147/NDT.S117146 10.1176/appi.ajp.2013.13030392 10.1001/jamapsychiatry.2017.3739 10.1016/j.jad.2020.01.002 10.1093/bja/57.2.197 10.1093/ijnp/pyz039 10.1017/S0033291714001603 10.1016/j.pbb.2013.11.033 10.1192/bjp.134.4.382 10.1016/S0006-3223(99)00230-9 10.1001/archpsyc.63.8.856 10.1093/ijnp/pyv124 10.1007/s00213-014-3664-5 10.1016/j.genhosppsych.2015.01.003 10.2147/NDT.S135623 10.1080/14737175.2019.1554434 10.1016/S0924-977X(96)00042-9 10.1111/pcn.12902 10.1176/appi.ajp.2018.17060720 10.1176/appi.ajp.2019.19020172 10.1002/14651858.CD011612.pub2 10.1007/s00406-016-0692-7 10.1016/j.biopsych.2015.10.018 10.1097/00000542-198003000-00008 10.1016/j.psychres.2016.03.034 10.1038/tp.2015.136 10.1124/jpet.116.239228 10.1023/A:1024465317902 10.1124/pr.117.015198 10.1016/j.jad.2019.11.086 10.1093/ajhp/zxz065 |
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| Keywords | Rapid-acting antidepressant ( Ketamine Arketamine Major depressive disorder Treatment-resistant depression (R)-Ketamine |
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(−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label... We aimed to analyze the efficacy and safety of arketamine, the R(-)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label... We aimed to analyze the efficacy and safety of arketamine, the R(−)-enantiomer of ketamine, for treatment-resistant depression (TRD) in humans. Open-label... |
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| SubjectTerms | Enantiomers Intravenous administration Ketamine Medicine Medicine & Public Health Mental depression Neurosciences Psychiatry Short Communication Treatment resistance |
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| Title | Intravenous arketamine for treatment-resistant depression: open-label pilot study |
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