Effects of mesenchymal stem cells versus curcumin on sonic hedgehog signaling in experimental model of Hepatocellular Carcinoma
Background Sonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut tissue homeostasis and development. Dysregulation of SHH leads to the development of HCC. Methods, and results The present study was co...
Saved in:
| Published in | Molecular biology reports Vol. 51; no. 1; p. 740 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Dordrecht
Springer Netherlands
01.12.2024
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Background
Sonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut tissue homeostasis and development. Dysregulation of SHH leads to the development of HCC.
Methods, and results
The present study was conducted to compare the effects of mesenchymal stem cells (MSCs) and curcumin on SHH molecular targets in an experimental model of HCC in rats. One hundred rats were divided equally into the following groups: control group, HCC group, HCC group received MSCs, HCC group received curcumin, and HCC group received MSCs and curcumin. Histopathological examinations were performed, and gene expression of SHH signaling target genes
(SHH, PTCH1, SMOH, and GLI1)
was assessed by real-time PCR in rat liver tissue. Results showed that SHH target genes were significantly upregulated in HCC-untreated rat groups and in MSC-treated groups, with no significant difference between them. Administration of curcumin with or without combined administration of MSCs led to a significant down-regulation of SHH target genes, with no significant differences between both groups. As regards the histopathological examination of liver tissues, both curcumin and MSCs, either through separate use or their combined use, led to a significant restoration of normal liver pathology.
Conclusions
In conclusion, SHH signaling is upregulated in the HCC experimental model. MSCs do not inhibit the upregulated SHH target genes in HCC. Curcumin use with or without MSCs administration led to a significant down-regulation of SHH signaling in HCC and a significant restoration of normal liver pathology. |
|---|---|
| AbstractList | BackgroundSonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut tissue homeostasis and development. Dysregulation of SHH leads to the development of HCC.Methods, and resultsThe present study was conducted to compare the effects of mesenchymal stem cells (MSCs) and curcumin on SHH molecular targets in an experimental model of HCC in rats. One hundred rats were divided equally into the following groups: control group, HCC group, HCC group received MSCs, HCC group received curcumin, and HCC group received MSCs and curcumin. Histopathological examinations were performed, and gene expression of SHH signaling target genes (SHH, PTCH1, SMOH, and GLI1) was assessed by real-time PCR in rat liver tissue. Results showed that SHH target genes were significantly upregulated in HCC-untreated rat groups and in MSC-treated groups, with no significant difference between them. Administration of curcumin with or without combined administration of MSCs led to a significant down-regulation of SHH target genes, with no significant differences between both groups. As regards the histopathological examination of liver tissues, both curcumin and MSCs, either through separate use or their combined use, led to a significant restoration of normal liver pathology.ConclusionsIn conclusion, SHH signaling is upregulated in the HCC experimental model. MSCs do not inhibit the upregulated SHH target genes in HCC. Curcumin use with or without MSCs administration led to a significant down-regulation of SHH signaling in HCC and a significant restoration of normal liver pathology. Sonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut tissue homeostasis and development. Dysregulation of SHH leads to the development of HCC.BACKGROUNDSonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut tissue homeostasis and development. Dysregulation of SHH leads to the development of HCC.The present study was conducted to compare the effects of mesenchymal stem cells (MSCs) and curcumin on SHH molecular targets in an experimental model of HCC in rats. One hundred rats were divided equally into the following groups: control group, HCC group, HCC group received MSCs, HCC group received curcumin, and HCC group received MSCs and curcumin. Histopathological examinations were performed, and gene expression of SHH signaling target genes (SHH, PTCH1, SMOH, and GLI1) was assessed by real-time PCR in rat liver tissue. Results showed that SHH target genes were significantly upregulated in HCC-untreated rat groups and in MSC-treated groups, with no significant difference between them. Administration of curcumin with or without combined administration of MSCs led to a significant down-regulation of SHH target genes, with no significant differences between both groups. As regards the histopathological examination of liver tissues, both curcumin and MSCs, either through separate use or their combined use, led to a significant restoration of normal liver pathology.METHODS, AND RESULTSThe present study was conducted to compare the effects of mesenchymal stem cells (MSCs) and curcumin on SHH molecular targets in an experimental model of HCC in rats. One hundred rats were divided equally into the following groups: control group, HCC group, HCC group received MSCs, HCC group received curcumin, and HCC group received MSCs and curcumin. Histopathological examinations were performed, and gene expression of SHH signaling target genes (SHH, PTCH1, SMOH, and GLI1) was assessed by real-time PCR in rat liver tissue. Results showed that SHH target genes were significantly upregulated in HCC-untreated rat groups and in MSC-treated groups, with no significant difference between them. Administration of curcumin with or without combined administration of MSCs led to a significant down-regulation of SHH target genes, with no significant differences between both groups. As regards the histopathological examination of liver tissues, both curcumin and MSCs, either through separate use or their combined use, led to a significant restoration of normal liver pathology.In conclusion, SHH signaling is upregulated in the HCC experimental model. MSCs do not inhibit the upregulated SHH target genes in HCC. Curcumin use with or without MSCs administration led to a significant down-regulation of SHH signaling in HCC and a significant restoration of normal liver pathology.CONCLUSIONSIn conclusion, SHH signaling is upregulated in the HCC experimental model. MSCs do not inhibit the upregulated SHH target genes in HCC. Curcumin use with or without MSCs administration led to a significant down-regulation of SHH signaling in HCC and a significant restoration of normal liver pathology. Sonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut tissue homeostasis and development. Dysregulation of SHH leads to the development of HCC. The present study was conducted to compare the effects of mesenchymal stem cells (MSCs) and curcumin on SHH molecular targets in an experimental model of HCC in rats. One hundred rats were divided equally into the following groups: control group, HCC group, HCC group received MSCs, HCC group received curcumin, and HCC group received MSCs and curcumin. Histopathological examinations were performed, and gene expression of SHH signaling target genes (SHH, PTCH1, SMOH, and GLI1) was assessed by real-time PCR in rat liver tissue. Results showed that SHH target genes were significantly upregulated in HCC-untreated rat groups and in MSC-treated groups, with no significant difference between them. Administration of curcumin with or without combined administration of MSCs led to a significant down-regulation of SHH target genes, with no significant differences between both groups. As regards the histopathological examination of liver tissues, both curcumin and MSCs, either through separate use or their combined use, led to a significant restoration of normal liver pathology. In conclusion, SHH signaling is upregulated in the HCC experimental model. MSCs do not inhibit the upregulated SHH target genes in HCC. Curcumin use with or without MSCs administration led to a significant down-regulation of SHH signaling in HCC and a significant restoration of normal liver pathology. Background Sonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut tissue homeostasis and development. Dysregulation of SHH leads to the development of HCC. Methods, and results The present study was conducted to compare the effects of mesenchymal stem cells (MSCs) and curcumin on SHH molecular targets in an experimental model of HCC in rats. One hundred rats were divided equally into the following groups: control group, HCC group, HCC group received MSCs, HCC group received curcumin, and HCC group received MSCs and curcumin. Histopathological examinations were performed, and gene expression of SHH signaling target genes (SHH, PTCH1, SMOH, and GLI1) was assessed by real-time PCR in rat liver tissue. Results showed that SHH target genes were significantly upregulated in HCC-untreated rat groups and in MSC-treated groups, with no significant difference between them. Administration of curcumin with or without combined administration of MSCs led to a significant down-regulation of SHH target genes, with no significant differences between both groups. As regards the histopathological examination of liver tissues, both curcumin and MSCs, either through separate use or their combined use, led to a significant restoration of normal liver pathology. Conclusions In conclusion, SHH signaling is upregulated in the HCC experimental model. MSCs do not inhibit the upregulated SHH target genes in HCC. Curcumin use with or without MSCs administration led to a significant down-regulation of SHH signaling in HCC and a significant restoration of normal liver pathology. |
| Author | Doudar, Noha A. Reyad, Hoda Ramadan Faruk, Eman Fouad, Hanan Rateb, Enas Ezzat Abdel-Tawab, Marwa Sayed Sedeak, Ahmed Yahia |
| Author_xml | – sequence: 1 givenname: Marwa Sayed surname: Abdel-Tawab fullname: Abdel-Tawab, Marwa Sayed email: Drmarwasayed2016@gmail.com organization: Medical Biochemistry Department, Faculty of Medicine, Beni-Suef University – sequence: 2 givenname: Hanan surname: Fouad fullname: Fouad, Hanan organization: Medical Biochemistry Department, Faculty of Medicine, Cairo University, Faculty of Medicine, Galala University – sequence: 3 givenname: Ahmed Yahia surname: Sedeak fullname: Sedeak, Ahmed Yahia organization: Anatomy and Embryology Department, Faculty of Medicine, Beni-Suef University – sequence: 4 givenname: Noha A. surname: Doudar fullname: Doudar, Noha A. organization: Clinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University – sequence: 5 givenname: Enas Ezzat surname: Rateb fullname: Rateb, Enas Ezzat organization: Physiology Department, Faculty of Medicine, Beni-Suef University – sequence: 6 givenname: Eman surname: Faruk fullname: Faruk, Eman organization: Department of Anatomy, Faculty of Medicine, Umm Al-Qura University, Department of Histology and Cytology, Faculty of Medicine, Benha University – sequence: 7 givenname: Hoda Ramadan surname: Reyad fullname: Reyad, Hoda Ramadan organization: Medical Biochemistry Department, Faculty of Medicine, Beni-Suef University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/38874802$$D View this record in MEDLINE/PubMed |
| BookMark | eNpdkU1r3DAQhkVJSTZp_kAPRdBLLm5HlqyPY1mSphDoJXchy2OvgyW5ll2aU_96tdmUQk9zmIeHeee9JGcxRSTkPYNPDEB9zowB5xXUogIjGa_4G7JjjeKVMEqfkR1wYJXQDbsglzk_AYBgqjknF1xrJTTUO_L7tu_Rr5mmngbMGP3hObiJ5hUD9ThNmf7EJW-Z-m3xWxgjTZHmFEdPD9gNeEgDzeMQ3TTGgZY1_ppxGQPGtWhC6nA6uu9xdms6CrfJLXTvFj_GFNw78rZ3U8br13lFHu9uH_f31cP3r9_2Xx6quWZ8rQS2olUenO8QpEHxEr02utGNlG1r6r52UpleaanRcC593RloQKnWeMWvyM1JOy_px4Z5tWHMx2tcxLRly0Fq1QCTUNCP_6FPaVtKvhNVa1G-WKgPr9TWBuzsXCK75dn-_WwB-AnIZRUHXP5pGNhjf_bUny392Zf-LOd_AF_9jZg |
| Cites_doi | 10.1038/s41392-023-01559-5 10.21608/smj.2019.13376.1019 10.1007/s11670-012-0271-z 10.3892/mmr.2014.2246 10.1007/s12015-014-9515-2 10.1186/s12967-022-03689-w 10.3390/nu11102376 10.1007/s11010-007-9682-4 10.3390/biomedicines9091188 10.1016/j.prp.2019.152556 10.15171/apb.2019.063 10.3390/ijms241713511 10.3390/ijms21197311 10.1002/cnr2.1921 10.7150/ijbs.33710 10.1016/j.apsb.2019.11.013 10.1177/2050312119875982 10.1002/ima.22746 10.3389/fonc.2022.729088 10.1038/nprot.2008.221 10.7150/ijbs.74123 10.3390/cells9092114 10.1158/0008-5472.CAN-19-1340 10.1089/ten.tea.2010.0732 10.1158/0008-5472.CAN-09-3012 10.3390/cancers13143427 10.1016/j.bbrc.2017.08.158 10.3390/cells9061370 10.21873/anticanres.14284 10.1186/s12935-019-1038-0 10.1111/jcmm.13651 10.1006/meth.2001.1262 10.1038/s41575-020-00381-6 10.3322/caac.21660 10.1186/s12935-022-02598-8 10.1002/ptr.5791 10.1016/j.jcyt.2014.05.006 10.3748/wjg.v23.i24.4330 10.3390/nu13030950 10.1002/med.21555 10.3389/fcell.2021.650664 10.3390/cells10010123 10.1002/ptr.7121 10.1002/cam4.4521 10.1159/000479998 10.1155/2015/172356 10.1016/j.ejmech.2022.114867 |
| ContentType | Journal Article |
| Copyright | The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. 2024. The Author(s), under exclusive licence to Springer Nature B.V. |
| Copyright_xml | – notice: The Author(s), under exclusive licence to Springer Nature B.V. 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. – notice: 2024. The Author(s), under exclusive licence to Springer Nature B.V. |
| DBID | CGR CUY CVF ECM EIF NPM 7TK 7TM 8FD FR3 K9. P64 RC3 7X8 |
| DOI | 10.1007/s11033-024-09613-3 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Neurosciences Abstracts Nucleic Acids Abstracts Technology Research Database Engineering Research Database ProQuest Health & Medical Complete (Alumni) Biotechnology and BioEngineering Abstracts Genetics Abstracts MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Genetics Abstracts Technology Research Database Nucleic Acids Abstracts ProQuest Health & Medical Complete (Alumni) Engineering Research Database Neurosciences Abstracts Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitleList | Genetics Abstracts MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Chemistry Biology |
| EISSN | 1573-4978 |
| ExternalDocumentID | 38874802 10_1007_s11033_024_09613_3 |
| Genre | Journal Article |
| GroupedDBID | --- -4W -56 -5G -BR -EM -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 123 1SB 203 28- 29M 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40E 53G 5QI 5RE 5VS 67N 67Z 6NX 78A 7X7 88A 88E 88I 8AO 8FE 8FH 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AABYN AACDK AAEOY AAFGU AAHNG AAIAL AAJBT AAJKR AANXM AANZL AAQLM AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO ABBBX ABBXA ABDZT ABECU ABELW ABFGW ABFTV ABHLI ABHQN ABJNI ABJOX ABKAS ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABSXP ABTEG ABTHY ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACBMV ACBRV ACBXY ACBYP ACDTI ACGFS ACGOD ACHSB ACHXU ACIGE ACIPQ ACKNC ACMDZ ACMLO ACOKC ACOMO ACPRK ACTTH ACVWB ACWMK ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADMDM ADOAH ADOXG ADRFC ADTPH ADURQ ADYFF ADYPR ADZKW AEBTG AEEQQ AEFIE AEFQL AEFTE AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AESTI AETLH AEVLU AEVTX AEXYK AFBBN AFEXP AFGCZ AFKRA AFLOW AFNRJ AFQWF AFWTZ AFZKB AGAYW AGDGC AGGBP AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AIMYW AITGF AJBLW AJDOV AJRNO AJZVZ AKMHD AKQUC ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG AOSHJ ARMRJ ASPBG AVWKF AXYYD AZFZN AZQEC B-. BA0 BBNVY BBWZM BDATZ BENPR BGNMA BHPHI BPHCQ BVXVI CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 DWQXO EBD EBLON EBS EIOEI EJD EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNUQQ GNWQR GQ6 GQ7 GQ8 GXS HCIFZ HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LK8 LLZTM M0L M1P M2P M4Y M7P MA- N2Q NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RIG RNI RNS ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S3A S3B SAP SBL SBY SCLPG SDH SDM SHX SISQX SJYHP SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZN T13 T16 TEORI TSG TSK TSV TUC TUS U2A U9L UG4 UKHRP UNUBA UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WH7 WJK WK6 WK8 YLTOR Z45 Z7U Z7V Z7W Z7Y Z82 Z83 Z87 Z8O Z8P Z8Q Z8S Z8V Z8W Z91 ZMTXR ZOVNA ZXP ~A9 ~EX ~KM AAHBH AAYZH CGR CUY CVF ECM EIF NPM 7TK 7TM 8FD FR3 K9. P64 RC3 7X8 |
| ID | FETCH-LOGICAL-p213t-4eb4b7c0acde069e41103329858566bb92f2a679f7868e9336c2d905077b9c73 |
| IEDL.DBID | AGYKE |
| ISSN | 0301-4851 1573-4978 |
| IngestDate | Sat Oct 26 04:49:28 EDT 2024 Thu Oct 10 17:04:40 EDT 2024 Sat Nov 02 12:15:01 EDT 2024 Sat Jun 15 09:00:52 EDT 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | Sonic hedgehog HCC MSCs Curcumin SHH And GLI1 SMOH PTCH1 |
| Language | English |
| License | 2024. The Author(s), under exclusive licence to Springer Nature B.V. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-p213t-4eb4b7c0acde069e41103329858566bb92f2a679f7868e9336c2d905077b9c73 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 38874802 |
| PQID | 3068284041 |
| PQPubID | 54080 |
| ParticipantIDs | proquest_miscellaneous_3068750160 proquest_journals_3068284041 pubmed_primary_38874802 springer_journals_10_1007_s11033_024_09613_3 |
| PublicationCentury | 2000 |
| PublicationDate | 2024-12-01 |
| PublicationDateYYYYMMDD | 2024-12-01 |
| PublicationDate_xml | – month: 12 year: 2024 text: 2024-12-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | Dordrecht |
| PublicationPlace_xml | – name: Dordrecht – name: Netherlands |
| PublicationSubtitle | An International Journal on Molecular and Cellular Biology |
| PublicationTitle | Molecular biology reports |
| PublicationTitleAbbrev | Mol Biol Rep |
| PublicationTitleAlternate | Mol Biol Rep |
| PublicationYear | 2024 |
| Publisher | Springer Netherlands Springer Nature B.V |
| Publisher_xml | – name: Springer Netherlands – name: Springer Nature B.V |
| References | Della Corte, Viscardi, Papaccio, Esposito, Martini, Ciardiello, Martinelli, Ciardiello, Morgillo (CR15) 2017; 23 Ding, Li, Zhang, Zhou, Wu (CR36) 2021; 10 Livak, Schmittgen (CR28) 2001; 25 Li, Cai, Li, Liu, Wang, Shi, Sun, Song, Wang (CR32) 2019; 41 Giordano, Tommonaro (CR20) 2019; 11 Abudeif (CR2) 2019; 23 Bissey, Mathot, Guix, Jasmin, Goddard, Costechareyre, Gadot, Delcros, Mali, Fasan, Arrigo (CR11) 2020; 80 Ślusarz, Shenouda, Sakla, Drenkhahn, Narula, MacDonald, Besch-Williford, Lubahn (CR44) 2010; 70 Ai, Ketabchi, Verdi, Gheibi, Khadem Haghighian, Kavianpour (CR54) 2019; 19 Soleimani, Nadri (CR25) 2009; 4 CR30 Jing, Wu, Wang, Luo, Lin, Fan, Zhou (CR33) 2023; 8 Terlapu, Gedela, Gangu, Pemula (CR4) 2022; 32 Wong, Kamarudin, Naidu (CR39) 2021; 13 Zhou, Zhou, Chen, Wang, Li, Chen, Zhang, Lu, Ding, Jiang (CR50) 2020; 10 Zhu, Yang, Chen, Jiang, Wang, Li, Wang, Meng, Zhu, Ma, Huang (CR42) 2017; 31 Qi, Zhou, Jiao, Wang, Zhao, Li, Chen, Yang, Zhu, Li (CR48) 2017; 42 CR3 CR6 Rahmatizadeh, Aziz, Khodadadi, Ataei, Ebrahimie, Rad, Pashaiasl (CR56) 2019; 9 Wang, Jiang, Zhou, Yu, Ding, Li, Zhou, Wang (CR38) 2019; 15 Feng, Zhu, Li, Yao, Song, Wang (CR9) 2022; 244 CR45 Giakoustidis, Giakoustidis, Mudan, Sklavos, Williams (CR18) 2015; 29 Ghasemi, Shafiee, Banikazemi, Pourhanifeh, Khanbabaei, Shamshirian, Moghadam, ArefNezhad, Sahebkar, Avan, Mirzaei (CR40) 2019; 215 Huang, El-Serag, Loomba (CR5) 2021; 18 Farghadani, Naidu (CR41) 2021; 13 Piñero, Dirchwolf, Pessôa (CR7) 2020; 9 Huang, Jiang, Chen, Han, Liu, Zhou, Dong, Xu (CR13) 2023; 19 Sundaresan, Subramanian (CR27) 2008; 310 Bariwal, Kumar, Dong, Mahato (CR10) 2019; 39 Zhang, Che, Pan, Su, Zheng, Yang, Zhang, Li, Wang, Liu (CR22) 2018; 22 Chiang, Hsieh, Lin, Lin, Tsai-Wu, Jiang (CR26) 2011; 17 Yang, Tian, Fan, Niu, Yan, Chen, Zheng, Zhang (CR21) 2022; 22 Doheny, Manore, Wong, Lo (CR35) 2020; 9 Abd-Allah, Shalaby, Amal, Abd Elkader, Hussein, Emam, Mazen, El Kateb, Atfy (CR53) 2014; 16 Che, Yuan, Jia, Ren (CR31) 2012; 24 CR55 García-Bernal, García-Arranz, Yáñez, Hervás-Salcedo, Cortés, Fernández-García, Hernando-Rodríguez, Quintana-Bustamante, Bueren, García-Olmo, Moraleda (CR47) 2021; 9 Wang, Kong, Li, Qian, Ma, Wang, Yu, Zhong (CR43) 2017; 493 CR51 Jeng, Jeng, Jeng, Sheen, Li, Leu, Tsay, Chang (CR14) 2019; 18 Zhang, Li, Zhu, Wen (CR23) 2022; 11 Liu, Zang, Huang, Liu (CR17) 2024; 7 Ma, Hu, Ullah, Zheng, Zhang, Sun (CR8) 2022; 12 Maulina, Hadikrishna, Hardianto, Sjamsudin, Pontjo, Yusuf (CR24) 2019; 7 Zhao, Li, Li, Chen, Lin, Zhang, Deng, Chen, Wang (CR16) 2022; 20 Chai, Sugumar, Alshawsh, Wong, Arya, Chong, Looi (CR12) 2021; 9 Slama, Ah-Pine, Khettab, Arcambal, Begue, Dutheil, Gasque (CR49) 2023; 24 CR29 Rathore, Mukim, Sharma, Devi, Nagar, Khalid (CR19) 2020; 7 Melzer, Ohe Jvd, Hass (CR52) 2020; 21 Ring, Kim, Kahn (CR57) 2014; 10 Sung, Ferlay, Siegel, Laversanne, Soerjomataram, Jemal, Bray (CR1) 2021; 71 Bhatia, Bhalerao, Cruz-Martins, Kumar (CR37) 2021; 35 Ahn (CR46) 2020; 40 Zhang, Tu, Yang, Li, Yao, Zheng, Liu (CR34) 2014; 10 |
| References_xml | – ident: CR45 – volume: 8 start-page: 315 issue: 1 year: 2023 ident: CR33 article-title: Hedgehog signaling in tissue homeostasis, cancers, and targeted therapies publication-title: Signal Transduct Target Therapy doi: 10.1038/s41392-023-01559-5 contributor: fullname: Zhou – volume: 23 start-page: 8 issue: 3 year: 2019 end-page: 12 ident: CR2 article-title: Epidemiology and risk factors of hepatocellular carcinoma in Egypt publication-title: Sohag Med J doi: 10.21608/smj.2019.13376.1019 contributor: fullname: Abudeif – volume: 24 start-page: 323 year: 2012 end-page: 331 ident: CR31 article-title: Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients publication-title: Chin J Cancer Res doi: 10.1007/s11670-012-0271-z contributor: fullname: Ren – volume: 41 start-page: 1991 issue: 3 year: 2019 end-page: 1997 ident: CR32 article-title: Combined inhibition of sonic hedgehog signaling and histone deacetylase is an effective treatment for liver cancer publication-title: Oncol Rep contributor: fullname: Wang – ident: CR51 – volume: 10 start-page: 749 issue: 2 year: 2014 end-page: 754 ident: CR34 article-title: Evaluation of Jagged2 and Gli1 expression and their correlation with prognosis in human hepatocellular carcinoma publication-title: Mol Med Rep doi: 10.3892/mmr.2014.2246 contributor: fullname: Liu – ident: CR29 – volume: 10 start-page: 512 year: 2014 end-page: 525 ident: CR57 article-title: Wnt/catenin signaling in adult stem cell physiology and disease publication-title: Stem Cell Reviews Rep doi: 10.1007/s12015-014-9515-2 contributor: fullname: Kahn – volume: 20 start-page: 1 issue: 1 year: 2022 end-page: 16 ident: CR16 article-title: CAFs-derived SCUBE1 promotes malignancy and stemness through the Shh/Gli1 pathway in hepatocellular carcinoma publication-title: J Translational Med doi: 10.1186/s12967-022-03689-w contributor: fullname: Wang – volume: 7 start-page: 273 issue: 1 year: 2020 end-page: 290 ident: CR19 article-title: Curcumin: a review for health benefits publication-title: Int J Res Rev contributor: fullname: Khalid – volume: 11 start-page: 2376 issue: 10 year: 2019 ident: CR20 article-title: Curcumin and cancer publication-title: Nutrients doi: 10.3390/nu11102376 contributor: fullname: Tommonaro – volume: 310 start-page: 209 year: 2008 end-page: 214 ident: CR27 article-title: Prevention of N-nitrosodiethylamine-induced hepatocarcinogenesis by S-allylcysteine publication-title: Mol Cell Biochem doi: 10.1007/s11010-007-9682-4 contributor: fullname: Subramanian – volume: 9 start-page: 1188 issue: 9 year: 2021 ident: CR12 article-title: The role of smoothened-dependent and-independent hedgehog signaling pathway in tumorigenesis publication-title: Biomedicines doi: 10.3390/biomedicines9091188 contributor: fullname: Looi – volume: 215 start-page: 152556 issue: 10 year: 2019 ident: CR40 article-title: Curcumin inhibits NF-kB and Wnt/β-catenin pathways in cervical cancer cells publication-title: Pathology-Research Pract doi: 10.1016/j.prp.2019.152556 contributor: fullname: Mirzaei – volume: 9 start-page: 539 issue: 4 year: 2019 ident: CR56 article-title: Bidirectional and opposite effects of naïve mesenchymal stem cells on tumor growth and progression publication-title: Adv Pharm Bull doi: 10.15171/apb.2019.063 contributor: fullname: Pashaiasl – volume: 24 start-page: 13511 issue: 17 year: 2023 ident: CR49 article-title: The dual role of mesenchymal stem cells in Cancer Pathophysiology: Pro-tumorigenic effects versus therapeutic potential publication-title: Int J Mol Sci doi: 10.3390/ijms241713511 contributor: fullname: Gasque – volume: 21 start-page: 7311 issue: 19 year: 2020 ident: CR52 article-title: Anti-tumor effects of exosomes derived from drug-incubated permanently growing human MSC publication-title: Int J Mol Sci doi: 10.3390/ijms21197311 contributor: fullname: Ohe Jvd, Hass – volume: 7 start-page: e1921 issue: 1 year: 2024 ident: CR17 article-title: Downregulation of Rab23 inhibits hepatocellular carcinoma by repressing SHH signaling pathway publication-title: Cancer Rep doi: 10.1002/cnr2.1921 contributor: fullname: Liu – volume: 15 start-page: 1200 issue: 6 year: 2019 ident: CR38 article-title: Potential mechanisms of action of curcumin for cancer prevention: focus on cellular signaling pathways and miRNAs publication-title: Int J Biol Sci doi: 10.7150/ijbs.33710 contributor: fullname: Wang – volume: 10 start-page: 1563 issue: 8 year: 2020 end-page: 1575 ident: CR50 article-title: Bone marrow mesenchymal stem cells-derived exosomes for penetrating and targeted chemotherapy of pancreatic cancer publication-title: Acta Pharm Sinica B doi: 10.1016/j.apsb.2019.11.013 contributor: fullname: Jiang – volume: 7 start-page: 2050312119875982 year: 2019 ident: CR24 article-title: The therapeutic activity of curcumin through its anti-cancer potential on oral squamous cell carcinoma: a study on Sprague Dawley rat publication-title: SAGE open Med doi: 10.1177/2050312119875982 contributor: fullname: Yusuf – volume: 32 start-page: 2107 issue: 6 year: 2022 end-page: 2136 ident: CR4 article-title: Intelligent diagnosis system of hepatitis C virus: a probabilistic neural network based approach publication-title: Int J Imaging Syst Technol doi: 10.1002/ima.22746 contributor: fullname: Pemula – volume: 12 start-page: 729088 year: 2022 ident: CR8 article-title: Molecular mechanisms involving the sonic hedgehog pathway in lung cancer therapy: recent advances publication-title: Front Oncol doi: 10.3389/fonc.2022.729088 contributor: fullname: Sun – volume: 4 start-page: 102 issue: 1 year: 2009 end-page: 106 ident: CR25 article-title: A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow publication-title: Nat Protoc doi: 10.1038/nprot.2008.221 contributor: fullname: Nadri – volume: 19 start-page: 2053 issue: 7 year: 2023 ident: CR13 article-title: Gli1 promotes the phenotypic transformation of valve interstitial cells through hedgehog pathway activation exacerbating calcific aortic valve disease publication-title: Int J Biol Sci doi: 10.7150/ijbs.74123 contributor: fullname: Xu – volume: 9 start-page: 2114 issue: 9 year: 2020 ident: CR35 article-title: Hedgehog signaling and truncated GLI1 in cancer publication-title: Cells doi: 10.3390/cells9092114 contributor: fullname: Lo – volume: 80 start-page: 1970 issue: 10 year: 2020 end-page: 1980 ident: CR11 article-title: Blocking SHH/Patched interaction triggers tumor growth inhibition through patched-induced apoptosis publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-19-1340 contributor: fullname: Arrigo – volume: 17 start-page: 2919 issue: 23–24 year: 2011 end-page: 2929 ident: CR26 article-title: Differences between chondrocytes and bone marrow-derived chondrogenic cells publication-title: Tissue Eng Part A doi: 10.1089/ten.tea.2010.0732 contributor: fullname: Jiang – volume: 70 start-page: 3382 issue: 8 year: 2010 end-page: 3390 ident: CR44 article-title: Common botanical compounds inhibit the hedgehog signaling pathway in prostate cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-09-3012 contributor: fullname: Lubahn – volume: 13 start-page: 3427 issue: 14 year: 2021 ident: CR41 article-title: Curcumin: modulator of key molecular signaling pathways in hormone-independent breast cancer publication-title: Cancers doi: 10.3390/cancers13143427 contributor: fullname: Naidu – volume: 493 start-page: 521 issue: 1 year: 2017 end-page: 527 ident: CR43 article-title: Curcumin inhibits bladder cancer stem cells by suppressing Sonic hedgehog pathway publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2017.08.158 contributor: fullname: Zhong – volume: 9 start-page: 1370 issue: 6 year: 2020 ident: CR7 article-title: Biomarkers in hepatocellular carcinoma: diagnosis, prognosis and treatment response assessment publication-title: Cells doi: 10.3390/cells9061370 contributor: fullname: Pessôa – ident: CR30 – volume: 40 start-page: 3039 issue: 6 year: 2020 end-page: 3047 ident: CR46 article-title: The role of MSCs in the tumor microenvironment and tumor progression publication-title: Anticancer Res doi: 10.21873/anticanres.14284 contributor: fullname: Ahn – volume: 19 start-page: 1 issue: 1 year: 2019 end-page: 13 ident: CR54 article-title: Mesenchymal stromal cells induce inhibitory effects on hepatocellular carcinoma through various signaling pathways publication-title: Cancer Cell Int doi: 10.1186/s12935-019-1038-0 contributor: fullname: Kavianpour – volume: 18 start-page: 4377 issue: 5 year: 2019 end-page: 4384 ident: CR14 article-title: Sonic hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma publication-title: Oncol Lett contributor: fullname: Chang – ident: CR6 – volume: 22 start-page: 3679 issue: 7 year: 2018 end-page: 3690 ident: CR22 article-title: The SHH/Gli axis regulates CD 90-mediated liver cancer stem cell function by activating the IL 6/JAK 2 pathway publication-title: J Cell Mol Med doi: 10.1111/jcmm.13651 contributor: fullname: Liu – volume: 25 start-page: 402 issue: 4 year: 2001 end-page: 408 ident: CR28 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2–∆∆CT method publication-title: Methods doi: 10.1006/meth.2001.1262 contributor: fullname: Schmittgen – volume: 18 start-page: 223 issue: 4 year: 2021 end-page: 238 ident: CR5 article-title: Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention publication-title: Nat Reviews Gastroenterol Hepatol doi: 10.1038/s41575-020-00381-6 contributor: fullname: Loomba – volume: 71 start-page: 209 issue: 3 year: 2021 end-page: 249 ident: CR1 article-title: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries publication-title: Cancer J Clin doi: 10.3322/caac.21660 contributor: fullname: Bray – volume: 22 start-page: 1 issue: 1 year: 2022 end-page: 13 ident: CR21 article-title: Integrated regulation of chondrogenic differentiation in mesenchymal stem cells and differentiation of cancer cells publication-title: Cancer Cell Int doi: 10.1186/s12935-022-02598-8 contributor: fullname: Zhang – volume: 31 start-page: 680 issue: 4 year: 2017 end-page: 688 ident: CR42 article-title: Curcumin suppresses lung cancer stem cells via inhibiting Wnt/β-catenin and sonic hedgehog pathways publication-title: Phytother Res doi: 10.1002/ptr.5791 contributor: fullname: Huang – volume: 16 start-page: 1197 issue: 9 year: 2014 end-page: 1206 ident: CR53 article-title: Effect of bone marrow–derived mesenchymal stromal cells on hepatoma publication-title: Cytotherapy doi: 10.1016/j.jcyt.2014.05.006 contributor: fullname: Atfy – ident: CR3 – volume: 23 start-page: 4330 issue: 24 year: 2017 ident: CR15 article-title: Implication of the hedgehog pathway in hepatocellular carcinoma publication-title: World J Gastroenterol doi: 10.3748/wjg.v23.i24.4330 contributor: fullname: Morgillo – volume: 13 start-page: 950 issue: 3 year: 2021 ident: CR39 article-title: Anticancer mechanism of curcumin on human glioblastoma publication-title: Nutrients doi: 10.3390/nu13030950 contributor: fullname: Naidu – volume: 39 start-page: 1137 issue: 3 year: 2019 end-page: 1204 ident: CR10 article-title: Design of hedgehog pathway inhibitors for cancer treatment publication-title: Med Res Rev doi: 10.1002/med.21555 contributor: fullname: Mahato – volume: 9 start-page: 650664 year: 2021 ident: CR47 article-title: The current status of mesenchymal stromal cells: controversies, unresolved issues and some promising solutions to improve their therapeutic efficacy publication-title: Front cell Dev Biology doi: 10.3389/fcell.2021.650664 contributor: fullname: Moraleda – volume: 10 start-page: 123 issue: 1 year: 2021 ident: CR36 article-title: Hedgehog signaling, a critical pathway governing the development and progression of hepatocellular carcinoma publication-title: Cells doi: 10.3390/cells10010123 contributor: fullname: Wu – volume: 35 start-page: 4913 issue: 9 year: 2021 end-page: 4929 ident: CR37 article-title: Curcumin and cancer biology: focusing regulatory effects in different signalling pathways publication-title: Phytother Res doi: 10.1002/ptr.7121 contributor: fullname: Kumar – volume: 11 start-page: 931 issue: 4 year: 2022 end-page: 943 ident: CR23 article-title: The role of mesenchymal stem cells in the occurrence, development, and therapy of hepatocellular carcinoma publication-title: Cancer Med doi: 10.1002/cam4.4521 contributor: fullname: Wen – volume: 42 start-page: 2242 issue: 6 year: 2017 end-page: 2254 ident: CR48 article-title: Exosomes derived from human bone marrow mesenchymal stem cells promote tumor growth through hedgehog signaling pathway publication-title: Cell Physiol Biochem doi: 10.1159/000479998 contributor: fullname: Li – ident: CR55 – volume: 29 start-page: 209 year: 2015 end-page: 217 ident: CR18 article-title: Molecular signalling in hepatocellular carcinoma: role of and crosstalk among WNT/β-catenin, Sonic hedgehog, notch and Dickkopf-1 publication-title: Can J Gastroenterol Hepatol doi: 10.1155/2015/172356 contributor: fullname: Williams – volume: 244 start-page: 114867 year: 2022 ident: CR9 article-title: Current approaches and strategies to identify hedgehog signaling pathway inhibitors for cancer therapy publication-title: Eur J Med Chem doi: 10.1016/j.ejmech.2022.114867 contributor: fullname: Wang |
| SSID | ssj0004175 |
| Score | 2.4271848 |
| Snippet | Background
Sonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role... Sonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in gut... BackgroundSonic Hedgehog (SHH) is a fundamental signaling pathway that controls tissue reconstruction, stem cell biology, and differentiation and has a role in... |
| SourceID | proquest pubmed springer |
| SourceType | Aggregation Database Index Database Publisher |
| StartPage | 740 |
| SubjectTerms | Animal Anatomy Animal Biochemistry Animals Biomedical and Life Sciences Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell differentiation Curcumin Curcumin - pharmacology Disease Models, Animal Down-regulation Gene expression Gene Expression Regulation, Neoplastic - drug effects Gene regulation Hedgehog protein Hedgehog Proteins - genetics Hedgehog Proteins - metabolism Hepatocellular carcinoma Histology Homeostasis Life Sciences Liver Liver - drug effects Liver - metabolism Liver - pathology Liver cancer Liver Neoplasms - genetics Liver Neoplasms - metabolism Liver Neoplasms - pathology Male Mesenchymal Stem Cell Transplantation - methods Mesenchymal stem cells Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Morphology Original Article Patched-1 Receptor - genetics Patched-1 Receptor - metabolism Pathology Rats Signal transduction Signal Transduction - drug effects Stem cells Zinc Finger Protein GLI1 - genetics Zinc Finger Protein GLI1 - metabolism |
| Title | Effects of mesenchymal stem cells versus curcumin on sonic hedgehog signaling in experimental model of Hepatocellular Carcinoma |
| URI | https://link.springer.com/article/10.1007/s11033-024-09613-3 https://www.ncbi.nlm.nih.gov/pubmed/38874802 https://www.proquest.com/docview/3068284041 https://www.proquest.com/docview/3068750160 |
| Volume | 51 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1NT9wwEB3xIdReSku_tlBkJI41SmKvYx9XK-iqSD0tEpyi2Ot0q2oTRJIDXPjrnXGSphJcONsZaTKO_ZyZNw_gVCNMoHQWzyXCNym95TpfGS4LKVLrcctchSrfn2pxJX9cT69HHncodh8ykmGjHrluMcmO4ZHCSaVEcLENuz3xdHf2_ebyfKRDxqG_LoF9LhFR9FyZ5608hyyfZEXDYXOxD8uBstPVmPw5axt75h6ednB8iR9v4U0PPtmsWy3vYMuXB7DXyVHeH8Cr-aD-9h4eu7bGNasKtiGGklvfb_BZ6vvM6G9_zaigo62Za-9cu_ldsqpkNTXaZWv6R7eufjEqDsmJ785w-H8tARYEeMj2Ao_DpiKDVA_L5iRtVFab_AMsL86X8wXvxRr4bRKLhmOUpU1dlLuVj5TxMviZGMo7KmWtSYokV6kpUq20N0Iol6xMhHA0tcal4iPslFXpPwPTsUOQiHOVttIV3uZGF0qm08JMtS2mEzgaIpb1H1yd4c0H744SYz-Bk3_D-M7Igbz0VdvNQYAUq2gCn7pIZ7ddT49M4GYrdZRM4NsQttH42NqZfMowdlmIXSa-vGz6IbxOKPKhHOYIdpq71n9FUNPY434RH8P2VTL7C2327iM |
| link.rule.ids | 315,783,787,27936,27937,41093,41535,42162,42604,52123,52246 |
| linkProvider | Springer Nature |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV07T-QwEB7x0AkaxOOA5XU-ifIsJbHXsUu0Ai3PapHootjr3F6xCSKbgoq_zoyTsEhHQ21nJPtz7M-emW8AzjXSBHJn8VwifZPSW67zqeGykCK1HrfMaYjyfVDjR3nzNHzqksLqPtq9d0mGnXqZ7BZT3TE8UziVKRFcrMI66auTYv5jcrHMhoyDvC5xfS6RUHSpMl_b-IpY_ucUDWfN1TZsdSSRXbSo7sCKL3fhR1s28nUXNkZ9lbY9eGvlh2tWFWxOmURu9jrHb0mfmdGrfM0o8KKpmWteXDP_V7KqZDUJ4rIZvaXNqr-Mgjhyyktn2PxZ85-FQjlke4zH1qIigxS3ykZUgqis5vlPmFxdTkZj3hVV4M9JLBYc0ZA2dVHupj5SxsswJYkh_6BS1pqkSHKVmiLVSnsjhHLJ1ERIG1NrXCr2Ya2sSn8ITMcOyRz2VdpKV3ibG10omQ4LM9S2GA7gpJ_arPsx6gxvKHjHkwjSAH5_NOOc0QDy0ldN2weJTKyiARy0kGTPrfZGJnBTlDpKBvCnx2hpfCnBTGPKEOYswJyJo-91_wUb48n9XXZ3_XB7DJsJLZgQwnICa4uXxp8iEVnYs7Du3gEEfdQi |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwEB7BVjwuPMproYCROJI2ib2OfayWLgtFFYcilVNkOzaL0CarJjmUC3-dmTzYCnpBnOOM4szE_pyZ-T6A1wphAqWzIiMQvgnhbaRMoSMRBM-sxyWz6Kp8T-Tys_hwNju71MXfVbuPKcm-p4FYmsrmYFOEg23jW0IaZLi_RCRZwiN-HXYEMSNNYOfw3Zfjo21vZNKR7RLyjwTCi6Fx5morV8HMv1Kk3c6zuAtmfOa-4OT7ftvYfffjDzrH_5nUPbgzwFJ22MfRfbjmy1240QtVXuzCrfmoC_cAfvaExzWrAltT75JbXazxXmKEZpQHqBmVerQ1c-25a9ffSlaVrCYKXraiv3er6iujshFDnfAML19WGWCdNA_ZXuJG2VRkkCpl2ZxEj8pqbR7C6eLodL6MBhmHaJMmvInQ_8JmLjau8LHUXnTzTDVlJKW0VqchNTLTIVNSec25dGmhYwSqmdUu449gUlalfwJMJQ7hI46VygoXvDVaBSmyWdAzZcNsCnuj-_LhU6xzPBPhqVJgIEzh1e_L-M5oAqb0VduPQeiUyHgKj3u355ue7SPnuAwLFadTeDO6cGt8S_pMc8rRd3nnu5w__bfhL-Hmp7eL_OP7k-NncDulIOhqZvZg0py3_jkin8a-GIL7F72E-fI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Effects+of+mesenchymal+stem+cells+versus+curcumin+on+sonic+hedgehog+signaling+in+experimental+model+of+Hepatocellular+Carcinoma&rft.jtitle=Molecular+biology+reports&rft.au=Abdel-Tawab%2C+Marwa+Sayed&rft.au=Fouad%2C+Hanan&rft.au=Sedeak%2C+Ahmed+Yahia&rft.au=Doudar%2C+Noha+A&rft.date=2024-12-01&rft.pub=Springer+Nature+B.V&rft.issn=0301-4851&rft.eissn=1573-4978&rft.volume=51&rft.issue=1&rft.spage=740&rft_id=info:doi/10.1007%2Fs11033-024-09613-3&rft.externalDBID=HAS_PDF_LINK |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0301-4851&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0301-4851&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0301-4851&client=summon |