Programmed Cell Death, from a Cancer Perspective: An Overview

• Published in: Molecular diagnosis & therapy Vol. 22; no. 3; pp. 281 - 295
• Main Authors: Mishra, Abhay P., Salehi, Bahare, Sharifi-Rad, Mehdi, Pezzani, Raffaele, Kobarfard, Farzad, Sharifi-Rad, Javad, Nigam, Manisha
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2018; Springer Nature B.V
• Subjects: Antineoplastic Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; Apoptosis - genetics; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Autophagy; Autophagy - drug effects; Autophagy - genetics; Autophagy-Related Proteins - genetics; Autophagy-Related Proteins - metabolism; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Cancer therapies; Cell death; Cell division; Gene Expression Regulation, Neoplastic; Homeostasis; Human Genetics; Humans; Kinases; Laboratory Medicine; Ligands; Molecular Medicine; Molecular Targeted Therapy - methods; Morphology; Mortality; Necrosis - genetics; Necrosis - metabolism; Necrosis - pathology; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - genetics; Neoplasm Proteins - metabolism; Neoplasms - drug therapy; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Pathogenesis; Pharmacotherapy; Protein Kinases - genetics; Protein Kinases - metabolism; Proteins; Review Article; Signal Transduction; Therapeutic applications; Therapy; Tumor necrosis factor-TNF; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism

Programmed cell death (PCD) is probably the most widely discussed subject among the topics of cancer therapy. Over the last 2 decades an astonishing boost in our perception of cell death has been seen, and its role in cancer and cancer therapy has been thoroughly investigated. A number of discoverie...