Misalignment of Circadian Rhythms in Diet-Induced Obesity

• Published in: Advances in experimental medicine and biology Vol. 1460; p. 27
• Main Author: Engin, Atilla
• Format: Journal Article
• Language: English
• Published: United States 2024
• Subjects: Animals; Circadian Clocks - genetics; Circadian Clocks - physiology; Circadian Rhythm - physiology; Diet, Ketogenic - adverse effects; Feeding Behavior - physiology; Humans; Obesity - etiology; Obesity - metabolism; Obesity - physiopathology; Suprachiasmatic Nucleus - metabolism; Suprachiasmatic Nucleus - physiology; Suprachiasmatic Nucleus - physiopathology; Obesity; Suprachiasmatic nucleus (SCN); Brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like 1 (BMAL1); N-methyl-D-aspartate receptor (NMDAR); Nicotinamide phosphoryl transferase; Circadian rhythm; Cryptochrome 1 (CRY1); Mammalian target of rapamycin (mTOR); Circadian locomotor output cycles kaput (CLOCK) genes; Calorie restriction; Peroxisome proliferator-activated receptor (PPAR); Adenosine monophosphate-activated protein kinase (AMPK); Resistin

The biological clocks of the circadian timing system coordinate cellular and physiological processes and synchronize them with daily cycles. While the central clock in the suprachiasmatic nucleus (SCN) is mainly synchronized by the light/dark cycles, the peripheral clocks react to other stimuli, inc...