Mitochondrial tRNA(Ser(UCN)) variants in 2651 Han Chinese subjects with hearing loss

• Published in: Mitochondrion Vol. 23; p. 17
• Main Authors: Tang, Xiaowen, Zheng, Jing, Ying, Zhengbiao, Cai, Zhaoyang, Gao, Yinglong, He, Zheyun, Yu, Han, Yao, Juan, Yang, Yaling, Wang, Hui, Chen, Ye, Guan, Min-Xin
• Format: Journal Article
• Language: English
• Published: Netherlands 01.07.2015
• Subjects: Adolescent; Adult; Aged; Asian Continental Ancestry Group; Child; Child, Preschool; Female; Gene Frequency; Genetic Predisposition to Disease; Hearing Loss - genetics; Humans; Male; Middle Aged; Mutation; RNA, Transfer, Ser - genetics; Young Adult; Mitochondria; Mutation; tRNA; Hearing loss; Incidence; Spectrum

Mutations in the mitochondrial DNA have been associated with hearing loss. However, the prevalence and spectrum of mitochondrial tRNA mutations in hearing-impaired subjects are poorly understood. In this report, we have investigated the prevalence and spectrum of mitochondrial tRNA(Ser(UCN)) mutatio...