Targeting prostate-specific membrane antigen for personalized therapies in prostate cancer: morphologic and molecular backgrounds and future promises

• Published in: Journal of biological regulators and homeostatic agents Vol. 28; no. 4; p. 555
• Main Authors: Santoni, M, Scarpelli, M, Mazzucchelli, R, Lopez-Beltran, A, Cheng, L, Cascinu, S, Montironi, R
• Format: Journal Article
• Language: English
• Published: Italy 01.10.2014
• Subjects: Antigens, Surface - analysis; Antigens, Surface - physiology; Glutamate Carboxypeptidase II - analysis; Glutamate Carboxypeptidase II - antagonists & inhibitors; Glutamate Carboxypeptidase II - physiology; Humans; Male; Precision Medicine; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - etiology; Prostatic Neoplasms - pathology

Prostate-specific membrane antigen (PSMA) is an integral, non-shed membrane glycoprotein that is highly expressed on prostate epithelial cells and strongly upregulated in prostate cancer (PCa). Prostatic neoplastic transformation results in the transfer of PSMA from the apical membrane to the lumina...