LncRNA UCA1 affects osteoblast proliferation and differentiation by regulating BMP-2 expression

• Published in: European review for medical and pharmacological sciences Vol. 23; no. 16; p. 6774
• Main Authors: Zhang, R-F, Liu, J-W, Yu, S-P, Sun, D, Wang, X-H, Fu, J-S, Xie, Z
• Format: Journal Article
• Language: English
• Published: Italy 01.08.2019
• Subjects: Animals; Bone Morphogenetic Protein 2 - genetics; Cell Differentiation - genetics; Cell Line; Cell Proliferation - genetics; Gene Knockout Techniques; Humans; Mice; Osteoblasts - metabolism; Osteoblasts - pathology; Osteogenesis - genetics; Osteoporosis - blood; Osteoporosis - genetics; RNA, Long Noncoding - blood; RNA, Long Noncoding - genetics; Signal Transduction

The aim of this study was to detect the expression of long non-coding ribonucleic acid (lncRNA) urothelial carcinoma associated 1 (UCA1) in the plasma of patients with osteoporosis (OST), and to investigate its influences on the proliferation and differentiation of osteoblasts and its mechanism. Pla...