Outcomes with cangrelor versus clopidogrel on a background of bivalirudin: insights from the CHAMPION PHOENIX (A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention [PCI])

• Published in: JACC. Cardiovascular interventions Vol. 8; no. 3; p. 424
• Main Authors: White, Harvey D, Bhatt, Deepak L, Gibson, C Michael, Hamm, Christian W, Mahaffey, Kenneth W, Price, Matthew J, Steg, Ph Gabriel, Stone, Gregg W, Cortese, Bernardo, Wilensky, Michael, Deliargyris, Efthymios N, Liu, Tiepu, Prats, Jayne, Harrington, Robert A
• Format: Journal Article
• Language: English
• Published: United States 01.03.2015
• Subjects: Adenosine Monophosphate - adverse effects; Adenosine Monophosphate - analogs & derivatives; Adenosine Monophosphate - therapeutic use; Aged; Anticoagulants - adverse effects; Anticoagulants - therapeutic use; Chi-Square Distribution; Coronary Artery Disease - diagnosis; Coronary Artery Disease - mortality; Coronary Artery Disease - therapy; Coronary Thrombosis - etiology; Coronary Thrombosis - prevention & control; Double-Blind Method; Female; Hemorrhage - chemically induced; Hirudins - adverse effects; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardial Infarction - etiology; Myocardial Infarction - prevention & control; Odds Ratio; Peptide Fragments - adverse effects; Peptide Fragments - therapeutic use; Percutaneous Coronary Intervention - adverse effects; Percutaneous Coronary Intervention - instrumentation; Percutaneous Coronary Intervention - mortality; Platelet Aggregation Inhibitors - adverse effects; Platelet Aggregation Inhibitors - therapeutic use; Recombinant Proteins - adverse effects; Recombinant Proteins - therapeutic use; Risk Factors; Stents; Ticlopidine - adverse effects; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; Time Factors; Treatment Outcome; CHAMPION PHOENIX; cangrelor; bivalirudin; stent thrombosis

The aim of this study was to examine the efficacy and bleeding outcomes of cangrelor in patients in the CHAMPION PHOENIX (A Clinical Trial Comparing Cangrelor to Clopidogrel Standard Therapy in Subjects Who Require Percutaneous Coronary Intervention [PCI]) who underwent percutaneous coronary interve...