Anticancer effects of Lanostane against human gastric cancer cells involves autophagy, apoptosis and modulation of m-TOR/PI3K/AKT signalling pathway

• Published in: Journal of B.U.ON. : official journal of the Balkan Union of Oncology Vol. 25; no. 3; p. 1463
• Main Authors: Peng, Xiulan, Ruan, Changli, Lei, Changjiang, He, Anbing, Wang, Xia, Luo, Renfeng, Cai, Yahong, Dong, Weiguo, Lin, Jun
• Format: Journal Article
• Language: English
• Published: Greece 01.05.2020
• Subjects: Antineoplastic Agents - pharmacology; Apoptosis - drug effects; Autophagy - drug effects; Cell Line, Tumor; Cell Proliferation - drug effects; Humans; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction - drug effects; Stomach Neoplasms - drug therapy; Stomach Neoplasms - metabolism; TOR Serine-Threonine Kinases - metabolism

Gastric carcinoma is the fourth leading cause of cancer-related morbidity throughout the globe. There are limited clinical therapies for gastric cancer due to lack of effective drugs and ambiguity in molecular mechanisms. As such there is a pressing need for novel and effective anticancer drugs for...