RPTPα controls epithelial adherens junctions, linking E-cadherin engagement to c-Src-mediated phosphorylation of cortactin

• Published in: Journal of cell science Vol. 127; no. Pt 11; p. 2420
• Main Authors: Truffi, Marta, Dubreuil, Véronique, Liang, Xuan, Vacaresse, Nathalie, Nigon, Fabienne, Han, Siew Ping, Yap, Alpha S, Gomez, Guillermo A, Sap, Jan
• Format: Journal Article
• Language: English
• Published: England 01.06.2014
• Subjects: Actins - metabolism; Adherens Junctions - genetics; Adherens Junctions - metabolism; Caco-2 Cells; Cadherins - metabolism; Cell Adhesion - genetics; Cortactin - genetics; Cortactin - metabolism; Epithelial Cells - physiology; HEK293 Cells; Humans; Mutation - genetics; Organ Culture Techniques; Organogenesis - genetics; Phosphorylation - genetics; Protein Transport; Receptor-Like Protein Tyrosine Phosphatases, Class 4 - genetics; Receptor-Like Protein Tyrosine Phosphatases, Class 4 - metabolism; RNA, Small Interfering - genetics; Signal Transduction - genetics; src-Family Kinases - metabolism; Cortactin; c-Src; Adherens junctions; Tyrosine phosphatase; E-cadherin

Epithelial junctions are fundamental determinants of tissue organization, subject to regulation by tyrosine phosphorylation. Homophilic binding of E-cadherin activates tyrosine kinases, such as Src, that control junctional integrity. Protein tyrosine phosphatases (PTPs) also contribute to cadherin-b...