Inhibitory effect of Aphidicolin - a tetracyclic diterpene - on the proliferation and apoptotic induction in human cervical cancer (HeLa) cells

• Published in: Journal of B.U. ON. Vol. 20; no. 6; p. 1480
• Main Authors: Yu, En-Yan, Zhao, Rui-Yan, Wang, Dong-Sheng
• Format: Journal Article
• Language: English
• Published: Greece 01.11.2015
• Subjects: Aphidicolin - pharmacology; Apoptosis - drug effects; Cell Proliferation - drug effects; Female; HeLa Cells; Humans; Membrane Potential, Mitochondrial - drug effects; Uterine Cervical Neoplasms - drug therapy; Uterine Cervical Neoplasms - pathology

The objective of the present work was to investigate the antitumor and apoptotic effect of aphidicolin against human cervical cancer (HeLa) cells. Flow cytometry was performed to detect alterations in the mitochondrial membrane potential loss (ΔΨm) after aphidicolin treatment. Cell viability was ass...