Quercetin inhibition of myocardial fibrosis through regulating MAPK signaling pathway via ROS

• Published in: Pakistan journal of pharmaceutical sciences Vol. 32; no. 3 Special; p. 1355
• Main Authors: Min, Zhang, Yangchun, Li, Yuquan, Wang, Changying, Zhang
• Format: Journal Article
• Language: English
• Published: Pakistan 01.05.2019
• Subjects: Angiotensin II - metabolism; Angiotensin II - pharmacology; Animals; Cardiotonic Agents - pharmacology; Cell Proliferation - drug effects; Cells, Cultured; Fibroblasts - drug effects; Fibroblasts - metabolism; Fibroblasts - pathology; Fibrosis; Heart - drug effects; MAP Kinase Kinase 4 - metabolism; MAP Kinase Signaling System - drug effects; Myocardium - metabolism; Myocardium - pathology; Quercetin - pharmacology; Rats, Wistar; Reactive Oxygen Species - metabolism

Mitogen-activated protein kinase (MAPK) cascades are important players in the cellular signal pathways, and the deregulation of MAPKs is involved in a variety of diseases, especially cardiovascular disorders. This study was designed to investigate the effects of quercetin on proliferation of cardiac...