Invited review DNA copy number changes as diagnostic tools for lung cancer

• Published in: Thorax Vol. 69; no. 5; p. 495
• Main Author: Bowcock, Anne M
• Format: Journal Article
• Language: English
• Published: England 01.05.2014
• Subjects: Comparative Genomic Hybridization - methods; DNA Copy Number Variations; DNA, Neoplasm - genetics; Humans; Lung Neoplasms - diagnosis; Lung Neoplasms - genetics; Predictive Value of Tests; Lung Cancer

Lung cancer usually presents as advanced stage disease and there is a need for early diagnosis so that appropriate treatments can be provided prior to tumour progression. Copy number variation is frequently detected in tumours and can contribute to tumour progression. This is because regions harbour...