Remote ischemic post-conditioning of the lower limb during primary percutaneous coronary intervention safely reduces enzymatic infarct size in anterior myocardial infarction: a randomized controlled trial

• Published in: JACC. Cardiovascular interventions Vol. 6; no. 10; p. 1055
• Main Authors: Crimi, Gabriele, Pica, Silvia, Raineri, Claudia, Bramucci, Ezio, De Ferrari, Gaetano M, Klersy, Catherine, Ferlini, Marco, Marinoni, Barbara, Repetto, Alessandra, Romeo, Maurizio, Rosti, Vittorio, Massa, Margherita, Raisaro, Arturo, Leonardi, Sergio, Rubartelli, Paolo, Oltrona Visconti, Luigi, Ferrario, Maurizio
• Format: Journal Article
• Language: English
• Published: United States 01.10.2013
• Subjects: Aged; Anterior Wall Myocardial Infarction - blood; Anterior Wall Myocardial Infarction - diagnosis; Anterior Wall Myocardial Infarction - physiopathology; Anterior Wall Myocardial Infarction - therapy; Area Under Curve; Biomarkers - blood; Creatine Kinase, MB Form - blood; Female; Humans; Ischemic Postconditioning - methods; Italy; Lower Extremity - blood supply; Magnetic Resonance Imaging; Male; Middle Aged; Myocardial Reperfusion Injury - blood; Myocardial Reperfusion Injury - diagnosis; Myocardial Reperfusion Injury - physiopathology; Myocardial Reperfusion Injury - prevention & control; Myocardium - enzymology; Myocardium - pathology; Percutaneous Coronary Intervention - adverse effects; Predictive Value of Tests; ROC Curve; Time Factors; Treatment Outcome; Italy; DE; cardiac magnetic resonance imaging; inhibitors of glycoprotein IIb/IIIa; myocardial infarction; primary percutaneous coronary intervention; CK-MB; LV; Thrombolysis In Myocardial Infarction; interquartile range; RIPC; STR; myocardial conditioning; MBG; STEMI; contrast enhanced cardiac magnetic resonance; T-weighted; left ventricle/ventricular; creatine kinase-myocardial band; myocardial blush grading; delayed enhancement; CI; remote ischemic post-conditioning; ce-CMR; primary angioplasty; IQR; myocardial reperfusion injury; LAD; pPCI; anti-GP IIb/IIIa; left anterior descending; TIMI; ST-segment resolution; T2W; confidence interval; ST-segment elevation myocardial infarction

This study sought to evaluate whether remote ischemic post-conditioning (RIPC) could reduce enzymatic infarct size in patients with anterior ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention (pPCI). Myocardial reperfusion injury may attenuate the benefi...