Apatinib suppresses the Proliferation and Apoptosis of Gastric Cancer Cells via the PI3K/Akt Signaling Pathway

• Published in: Journal of B.U.ON. : official journal of the Balkan Union of Oncology Vol. 24; no. 5; p. 1985
• Main Authors: Jia, Xiaoqiong, Wen, Zhenping, Sun, Qiuying, Zhao, Xiaohua, Yang, Hao, Shi, Xiaoyu, Xin, Tao
• Format: Journal Article
• Language: English
• Published: Greece 01.09.2019
• Subjects: Apoptosis - drug effects; Caspases - metabolism; Cell Line, Tumor; Cell Proliferation - drug effects; Humans; Phosphatidylinositol 3-Kinase - metabolism; Phosphorylation - drug effects; Proto-Oncogene Proteins c-akt - metabolism; Pyridines - pharmacology; Signal Transduction - drug effects; Stomach Neoplasms - drug therapy; Stomach Neoplasms - metabolism
• ISSN: 2241-6293

To observe the mechanism of the effects of Apatinib on the proliferation and apoptosis of human gastric cancer (HGC-27) cells via the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway through in vitro cytology experiments. The human gastric cancer HGC-27 cell line was tak...