2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines

• Published in: Journal of the American College of Cardiology Vol. 76; no. 25; p. 3022
• Main Authors: Ommen, Steve R, Mital, Seema, Burke, Michael A, Day, Sharlene M, Deswal, Anita, Elliott, Perry, Evanovich, Lauren L, Hung, Judy, Joglar, José A, Kantor, Paul, Kimmelstiel, Carey, Kittleson, Michelle, Link, Mark S, Maron, Martin S, Martinez, Matthew W, Miyake, Christina Y, Schaff, Hartzell V, Semsarian, Christopher, Sorajja, Paul
• Format: Journal Article
• Language: English
• Published: United States 22.12.2020
• Subjects: American Heart Association; Cardiology - methods; Cardiology - trends; Cardiomyopathy, Hypertrophic - diagnosis; Cardiomyopathy, Hypertrophic - therapy; Death, Sudden, Cardiac - prevention & control; Evidence-Based Medicine - standards; Humans; Patient Care Management - methods; Patient Care Management - standards; Patient Selection; Risk Adjustment; United States; United States; ACC/AHA Clinical Practice Guidelines; family screening; occupation; risk stratification; rhythm monitoring; echocardiography; pregnancy; septal reduction therapy; systolic dysfunction; sudden cardiac death; cardiovascular magnetic resonance; left ventricular outflow tract obstruction; septal alcohol ablation; physical activity; sarcomeric genes; exercise stress testing; atrial fibrillation; implantable cardioverter defibrillator; genetics; surgical myectomy; ventricular arrhythmias; shared decision-making; diastolic dysfunction; hypertrophic cardiomyopathy
• DOI: 10.1016/j.jacc.2020.08.044
• ISSN: 1558-3597

This executive summary of the hypertrophic cardiomyopathy clinical practice guideline provides recommendations and algorithms for clinicians to diagnose and manage hypertrophic cardiomyopathy in adult and pediatric patients as well as supporting documentation to encourage their use. A comprehensive literature search was conducted from January 1, 2010, to April 30, 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Collaboration, Agency for Healthcare Research and Quality reports, and other relevant databases. Many recommendations from the earlier hypertrophic cardiomyopathy guidelines have been updated with new evidence or a better understanding of earlier evidence. This summary operationalizes the recommendations from the full guideline and presents a combination of diagnostic work-up, genetic and family screening, risk stratification approaches, lifestyle modifications, surgical and catheter interventions, and medications that constitute components of guideline directed medical therapy. For both guideline-directed medical therapy and other recommended drug treatment regimens, the reader is advised to follow dosing, contraindications and drug-drug interactions based on product insert materials.