Akathisia and Restless Legs Syndrome: Solving the Dopaminergic Paradox

• Published in: Sleep medicine clinics Vol. 16; no. 2; p. 249
• Main Authors: Ferré, Sergi, Guitart, Xavier, Quiroz, César, Rea, William, García-Malo, Celia, Garcia-Borreguero, Diego, Allen, Richard P, Earley, Christopher J
• Format: Journal Article
• Language: English
• Published: United States 01.06.2021
• Subjects: Receptor heteromers; Restless legs syndrome; Striatum; Adenosine; Dopamine; Akathisia; Glutamate

Akathisia is an urgent need to move that is associated with treatment with dopamine receptor blocking agents (DRBAs) and with restless legs syndrome (RLS). The pathogenetic mechanism of akathisia has not been resolved. This article proposes that it involves an increased presynaptic dopaminergic tran...