Modulation of gut-specific mechanisms by chronic δ(9)-tetrahydrocannabinol administration in male rhesus macaques infected with simian immunodeficiency virus: a systems biology analysis

• Published in: AIDS research and human retroviruses Vol. 30; no. 6; p. 567
• Main Authors: Molina, Patricia E, Amedee, Angela M, LeCapitaine, Nicole J, Zabaleta, Jovanny, Mohan, Mahesh, Winsauer, Peter J, Vande Stouwe, Curtis, McGoey, Robin R, Auten, Matthew W, LaMotte, Lynn, Chandra, Lawrance C, Birke, Leslie L
• Format: Journal Article
• Language: English
• Published: United States 01.06.2014
• Subjects: Animals; CD4-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - immunology; Cytokines - secretion; Dronabinol - administration & dosage; Duodenum - pathology; Duodenum - virology; Gene Expression Profiling; Immunologic Factors - administration & dosage; Injections, Intravenous; Macaca mulatta; Male; Microarray Analysis; Simian Acquired Immunodeficiency Syndrome - drug therapy; Simian Acquired Immunodeficiency Syndrome - pathology; Simian Acquired Immunodeficiency Syndrome - virology; Simian Immunodeficiency Virus - isolation & purification; Systems Biology; T-Lymphocyte Subsets - immunology; Viral Load

Our studies have demonstrated that chronic Δ(9)-tetrahydrocannabinol (THC) administration results in a generalized attenuation of viral load and tissue inflammation in simian immunodeficiency virus (SIV)-infected male rhesus macaques. Gut-associated lymphoid tissue is an important site for HIV repli...