A Comprehensive Pan-Cancer Analysis of the Mitochondrial Uncoupling Protein UCP2, with a Focus on Sex and Gender-Related Aspects

• Published in: Cellular physiology and biochemistry Vol. 58; no. 5; p. 630
• Main Authors: Sadeghi, Soha, Checchetto, Vanessa, Varanita, Tatiana
• Format: Journal Article
• Language: English
• Published: Germany 27.10.2024
• Subjects: Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - mortality; Breast Neoplasms - pathology; Female; Humans; Male; Microsatellite Instability; Neoplasms - genetics; Neoplasms - metabolism; Neoplasms - pathology; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - mortality; Ovarian Neoplasms - pathology; Prognosis; Prostatic Neoplasms - genetics; Prostatic Neoplasms - metabolism; Prostatic Neoplasms - pathology; Sex Factors; Testicular Neoplasms - genetics; Testicular Neoplasms - metabolism; Testicular Neoplasms - pathology; Uncoupling Protein 2 - genetics; Uncoupling Protein 2 - metabolism; UCP2 ; Pan-cancer ; Gender-related cancers ; Expression ; Prognosis

Mitochondrial uncoupling protein 2 (UCP2) plays a crucial role in regulating oxidative stress and cellular metabolism, positioning it as an important subject in oncological research. The involvement of UCP2 in cancer is complex and context-dependent, suggesting it as a potential therapeutic target....