Vascular smooth muscle stiffness and its role in aging

• Published in: Current topics in membranes Vol. 86; pp. 217 - 253
• Main Authors: Trache, Andreea, Massett, Michael P, Woodman, Christopher R
• Format: Journal Article
• Language: English
• Published: United States 2020
• Subjects: Exercise; Cell adhesion; Vasoconstriction; Aging; Resistance arteries; Aorta; Cytoskeleton; Stiffness; Mechanical signaling; Vascular smooth muscle cells

Vascular smooth muscle cells (VSMC) are now considered important contributors to the pathophysiological and biophysical mechanisms underlying arterial stiffening in aging. Here, we review mechanisms whereby VSMC stiffening alters vascular function and contributes to the changes in vascular stiffenin...