A flavone, Wogonin from Scutellaria baicalensis inhibits the proliferation of human colorectal cancer cells by inducing of autophagy, apoptosis and G2/M cell cycle arrest via modulating the PI3K/AKT and STAT3 signalling pathways

• Published in: Journal of B.U.ON. : official journal of the Balkan Union of Oncology Vol. 24; no. 3; p. 1143
• Main Authors: Tan, Hao, Li, Xiang, Yang, Wei Han, Kang, Yong
• Format: Journal Article
• Language: English
• Published: Greece 01.05.2019
• Subjects: Apoptosis; Autophagy; Cell Proliferation; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Flavanones - pharmacology; Flavanones - therapeutic use; Humans; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; Scutellaria baicalensis; Signal Transduction; STAT3 Transcription Factor - metabolism
• ISSN: 2241-6293

The purpose of this study was to examine the anticancer effects of a flavone from Scutellaria baicalensis wogonin against a panel of colorectal cancer cells. The SW1417, SW48, DLD-1, HCT-15, LS-180 and CCD-18Co cell lines were used for the evaluation of the anticancer effects of wogonin. WST-1 and c...