Intracellular mechanisms of tumor cells' immunoresistance

• Published in: Acta biochimica Polonica Vol. 67; no. 2; p. 143
• Main Authors: Hermanowicz, Justyna, Sieklucka, Beata, Nosek, Krzysztof, Pawlak, Dariusz
• Format: Journal Article
• Language: English
• Published: Poland 22.04.2020
• Subjects: Animals; Antineoplastic Agents - pharmacology; B7-H1 Antigen - antagonists & inhibitors; B7-H1 Antigen - metabolism; CTLA-4 Antigen - antagonists & inhibitors; CTLA-4 Antigen - metabolism; Female; Humans; Immune Tolerance; Lymphocyte Activation - drug effects; Male; Molecular Targeted Therapy - methods; Programmed Cell Death 1 Receptor - antagonists & inhibitors; Programmed Cell Death 1 Receptor - metabolism; Signal Transduction - drug effects; T-Lymphocytes, Regulatory - immunology; Tumor Escape; Tumor Microenvironment - immunology
• DOI: 10.18388/abp.2020_2878

One of the main mechanisms for avoiding immune response by cancer cells is mediated by inducing an immunosuppressive environment in the tumor following activation of immune checkpoints, i.e. PD-1 or CTLA-4 receptor inhibitors on T lymphocytes. Interaction inhibition between PD-1 or CTLA-4 and their ligands (PD-L1, CD80, and CD85) leads to unblocking of the T-lymphocyte function, and thus destroys cancer cells. Certain intracellular signaling pathways are also involved in the development of tumor cell immunoresistance. Immunosuppressive pathways' activation blocking may increase the immunological anti-tumor control.