A CRITICAL REVIEW ON PHARMACOLOGICAL SIGNIFICANCE OF HYDROGEN SULFIDE (H₂S) ON NF-κB CONCENTRATION AND ICAM-1 EXPRESSION IN RENAL ISCHEMIA REPERFUSION INJURY

• Published in: Acta Poloniae pharmaceutica Vol. 74; no. 3; pp. 747 - 752
• Main Authors: Hashmp, Syed Fayaz, Sattar, Munavvar Z A, Rathore, Hassaan A, Ahmadi, Ashfaq, Johns, Edward J
• Format: Journal Article
• Language: English
• Published: Poland 01.05.2017
• Subjects: Acute Kidney Injury - drug therapy; Acute Kidney Injury - metabolism; Acute Kidney Injury - pathology; Animals; Humans; Hydrogen Sulfide - therapeutic use; Intercellular Adhesion Molecule-1 - metabolism; Kidney - drug effects; Kidney - metabolism; Kidney - pathology; Kidney Diseases - drug therapy; Kidney Diseases - metabolism; Kidney Diseases - pathology; NF-kappa B - metabolism; Reperfusion Injury - drug therapy; Reperfusion Injury - metabolism; Reperfusion Injury - pathology; Signal Transduction - drug effects

Until recently hydrogen sulfide (H2S) was the least appreciated of the three gasotransmitters but now recognized as 3Y gaseous mediator after nitric oxide(NO) and carbon monoxide (CO). H2S regulates a number of physiological processes like vasorelaxation, prevention of inflammation, leukocyte adhesi...