Circulating nucleic acids and infertility

• Published in: Gynécologie, obstétrique & fertilité Vol. 43; no. 9; pp. 593 - 598
• Main Authors: Scalici, E, Mullet, T, Ferrières Hoa, A, Gala, A, Loup, V, Anahory, T, Belloc, S, Hamamah, S
• Format: Journal Article
• Language: French
• Published: France 01.09.2015
• Subjects: Biomarkers - blood; DNA - blood; Female; Humans; Infertility - blood; Male; MicroRNAs - blood; Nucleic Acids - blood; Ovarian Reserve; Polycystic Ovary Syndrome - blood; Precision Medicine; Reproductive Techniques, Assisted; Spermatogenesis - physiology; microRNAs; Follicular micro-environment; Assistance médicale à la procréation; Assisted reproductive technology; Embryo quality; Circulating nucleic acids; Acides nucléiques circulants; microARNs; Infertilité masculine; Male infertility; ADN libre; Cell-free DNA; Qualité embryonnaire; Microenvironnement folliculaire; Réserve ovarienne; Ovarian reserve

Circulating nucleic acids (cell-free DNA and microRNAs) have for particularity to be easily detectable in the biological fluids of the body. Therefore, they constitute biomarkers of interest in female and male infertility care. Indeed, in female, they can be used to detect ovarian reserve disorders...