Myricetin exhibits anti-glioma potential by inducing mitochondrial-mediated apoptosis, cell cycle arrest, inhibition of cell migration and ROS generation

• Published in: Journal of B.U. ON. Vol. 21; no. 1; p. 182
• Main Authors: Li, Hu-Guang, Chen, Jun-Xia, Xiong, Jun-Hui, Zhu, Jin-Wei
• Format: Journal Article
• Language: English
• Published: Greece 01.01.2016
• Subjects: Apoptosis - drug effects; Brain Neoplasms - drug therapy; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Caspases - physiology; Cell Cycle Checkpoints - drug effects; Cell Line, Tumor; Cell Movement - drug effects; Flavonoids - pharmacology; Glioma - drug therapy; Glioma - metabolism; Glioma - pathology; Humans; Mitochondria - drug effects; Proto-Oncogene Proteins c-bcl-2 - analysis; Reactive Oxygen Species - metabolism

To study the antiproliferative effects of myricetin in human glioma U251 cells together with assessing its effects on cell cycle, apoptosis, apoptosis-related proteins, reactive oxygen species (ROS) generation and cell migration. Cell viability of human glioma cells after myricetin treatment was ass...