Cationic liposomes containing antioxidants reduces pulmonary injury in experimental model of sepsis: Liposomes antioxidants reduces pulmonary damage

• Published in: Respiratory physiology & neurobiology Vol. 231; pp. 55 - 62
• Main Authors: Galvão, Andre Martins, Galvão, Júlia Siqueira, Pereira, Marcela Araújo, Cadena, Pabyton Gonçalves, Magalhães, Nereide Stella Santos, Fink, James B, de Andrade, Armele Dornelas, Castro, Celia Maria Machado Barbosa de, de Sousa Maia, Maria Bernadete
• Format: Journal Article
• Language: English
• Published: Netherlands 01.09.2016
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Antioxidants - administration & dosage; Cations - chemistry; Cecum - injuries; Cells, Cultured; Disease Models, Animal; Drug Evaluation, Preclinical; Lipid Peroxidation - drug effects; Lipopolysaccharides; Liposomes - chemistry; Lung - drug effects; Lung - metabolism; Lung Injury - drug therapy; Lung Injury - metabolism; Macrophages - drug effects; Macrophages - metabolism; Male; Protective Agents - administration & dosage; Protein Carbonylation - drug effects; Random Allocation; Rats, Wistar; Sepsis - drug therapy; Sepsis - metabolism; Superoxides - metabolism; Liposome; Oxidative stress; Sepsis; Antioxidant; Pulmonary injury

The intracellular redox state of alveolar cells is a determining factor for tolerance to oxidative and pro-inflammatory stresses. This study investigated the effects of intratracheal co-administration of antioxidants encapsulated in liposomes on the lungs of rats subjected to sepsis. For this, male...