Effects of acetone cyanohydrin, a derivative of cassava, on motor activity and kidney and liver function in Wistar rats

• Published in: Neurologia (Barcelona, Spain) Vol. 34; no. 5; p. 300
• Main Authors: Rivadeneyra-Domínguez, E, J Rosas-Jarquín, C, Vázquez-Luna, A, Díaz-Sobac, R, Rodríguez-Landa, J F
• Format: Journal Article
• Language: English; Spanish
• Published: Spain 01.06.2019
• Subjects: Animals; Behavior, Animal - drug effects; Blood Chemical Analysis; Kidney - drug effects; Liver - drug effects; Manihot - toxicity; Motor Activity - drug effects; Nitriles - pharmacology; Rats; Rats, Wistar; Swimming; Yuca; Alteración motora; Nephrotoxic; Hepatotóxico; Neurotóxico; Nefrotóxico; Motor impairment; Acetona cianohidrina; Hepatotoxic; Neurotoxic; Acetone cyanohydrin; Cassava

Acetone cyanohydrin (ACH) is a toxic substance present in cassava roots (Manihot esculenta Crantz) which results from enzymatic hydrolysis of linamarin. Long-term consumption is associated with 2 neurological disorders: konzo and tropical ataxic neuropathy. Previous studies have evaluated behavioura...