Mast cell involvement in rheumatoid arthritis

• Published in: Journal of biological regulators and homeostatic agents Vol. 27; no. 3; p. 655
• Main Authors: Kritas, S K, Saggini, A, Varvara, G, Murmura, G, Caraffa, A, Antinolfi, P, Toniato, E, Pantalone, A, Neri, G, Frydas, S, Rosati, M, Tei, M, Speziali, A, Saggini, R, Pandolfi, F, Theoharides, T C, Conti, P
• Format: Journal Article
• Language: English
• Published: Italy 01.07.2013
• Subjects: Arthritis, Rheumatoid - etiology; Corticotropin-Releasing Hormone - physiology; Cytokines - physiology; Humans; Mast Cells - physiology; Tryptases - physiology

Autoimmunity is a failure of self-tolerance resulting in immune reactions against autologous antigen. Rheumatoid arthritis is characterized by inflammation of synovium associated with destruction of the join cartilage and bone. A role of mast cell-mediated inflammation and antibodies are involved in...