Phylogenetic analysis of human metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia
Human metapneumovirus (HMPV) is a recently discovered cause of viral respiratory infections. We describe clinical and molecular epidemiology of HMPV cases diagnosed in children with respiratory infection at University of Malaya Medical Centre, Kuala Lumpur, Malaysia. The prevalence rate of HMPV betw...
Saved in:
Published in | Tropical biomedicine Vol. 31; no. 3; pp. 562 - 566 |
---|---|
Main Authors | , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Malaysia
01.09.2014
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Human metapneumovirus (HMPV) is a recently discovered cause of viral respiratory infections. We describe clinical and molecular epidemiology of HMPV cases diagnosed in children with respiratory infection at University of Malaya Medical Centre, Kuala Lumpur, Malaysia. The prevalence rate of HMPV between 2010 and 2012 was 1.1%, and HMPV contributed 6.5% of confirmed viral respiratory infections. The HMPV patients had a median age of 1.6 years, and a median hospital admission of 4 days. The most common clinical presentations were fever, rhinitis, pneumonia, vomiting/diarrhoea, and bronchiolitis. Based on the partial sequences of F fusion gene from 26 HMPV strains, 14 (54%) were subgenotype A2b, which was predominant in 2010; 11 (42%) were subgenotype B1, which was predominant in 2012; and 1 (4%) was subgenotype A2a. Knowledge of the circulating subgenotypes in Malaysia, and the displacement of predominant subgenotypes within 3 years, is useful data for future vaccine planning. |
---|---|
AbstractList | Human metapneumovirus (HMPV) is a recently discovered cause of viral respiratory infections. We describe clinical and molecular epidemiology of HMPV cases diagnosed in children with respiratory infection at University of Malaya Medical Centre, Kuala Lumpur, Malaysia. The prevalence rate of HMPV between 2010 and 2012 was 1.1%, and HMPV contributed 6.5% of confirmed viral respiratory infections. The HMPV patients had a median age of 1.6 years, and a median hospital admission of 4 days. The most common clinical presentations were fever, rhinitis, pneumonia, vomiting/diarrhoea, and bronchiolitis. Based on the partial sequences of F fusion gene from 26 HMPV strains, 14 (54%) were subgenotype A2b, which was predominant in 2010; 11 (42%) were subgenotype B1, which was predominant in 2012; and 1 (4%) was subgenotype A2a. Knowledge of the circulating subgenotypes in Malaysia, and the displacement of predominant subgenotypes within 3 years, is useful data for future vaccine planning. |
Author | Sam, I C Hooi, P S Hassan, A de Bruyne, J A Mohamad Fakri, E F AbuBakar, S Nor'e, S S Chan, Y F Nathan, A M Jafar, F |
Author_xml | – sequence: 1 givenname: S S surname: Nor'e fullname: Nor'e, S S organization: Tropical Infectious Diseases Research and Education Centre (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 2 givenname: I C surname: Sam fullname: Sam, I C organization: Tropical Infectious Diseases Research and Education Centre (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 3 givenname: E F surname: Mohamad Fakri fullname: Mohamad Fakri, E F organization: Tropical Infectious Diseases Research and Education Centre (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 4 givenname: P S surname: Hooi fullname: Hooi, P S organization: Diagnostic Virology Laboratory, University Malaya Medical Centre, Kuala Lumpur, Malaysia – sequence: 5 givenname: A M surname: Nathan fullname: Nathan, A M organization: Department of Paediatrics, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 6 givenname: J A surname: de Bruyne fullname: de Bruyne, J A organization: Department of Paediatrics, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 7 givenname: F surname: Jafar fullname: Jafar, F organization: Tropical Infectious Diseases Research and Education Centre (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 8 givenname: A surname: Hassan fullname: Hassan, A organization: Tropical Infectious Diseases Research and Education Centre (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 9 givenname: S surname: AbuBakar fullname: AbuBakar, S organization: Tropical Infectious Diseases Research and Education Centre (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia – sequence: 10 givenname: Y F surname: Chan fullname: Chan, Y F organization: Tropical Infectious Diseases Research and Education Centre (TIDREC), Department of Medical Microbiology, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25382484$$D View this record in MEDLINE/PubMed |
BookMark | eNo1kElLxEAUhPsw4iz6F6SPHgwkrzvLHGVwwxE96Dm8dF4mLUl37EXJv3fA8VRV8FEFtWYLYw0t2CrNoEzyEtIlW3v_maa5rCp5zpaQiwpkJVdsfuvnwR7IUNCKo8Fh9tpz2_E-jmj4SAEnQ3G039pFz3G05sBVr4fWkeE_OvQcVQzEHflJOwzWzVybjlTQ1vij5c8RB-T7OE7R3fCXYzhu4AU763DwdHnSDfu4v3vfPSb714en3e0-mSDLQiILhZC2gLJtulaoEqhQnZJN1kAJogEoqOy2qciaqiywyohErgrMqSVscxAbdv3XOzn7FcmHetRe0TCgIRt9nRUA-VZCKo7o1QmNzUhtPTk9opvr_7vEL03HauU |
ContentType | Journal Article |
DBID | CGR CUY CVF ECM EIF NPM 7X8 |
DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
DatabaseTitleList | MEDLINE - Academic MEDLINE |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EndPage | 566 |
ExternalDocumentID | 25382484 |
Genre | Research Support, Non-U.S. Gov't Journal Article |
GeographicLocations | Malaysia |
GeographicLocations_xml | – name: Malaysia |
GroupedDBID | --- .3O 123 53G ACGFO ADBBV AEGXH AENEX AIAGR ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CUY CVF C~G DIK DYU EBD EBS ECGQY ECM EIF EJD EMOBN EOJEC F5P GX1 NPM OBODZ OK1 OZF P2P SV3 TR2 7X8 |
ID | FETCH-LOGICAL-p211t-46ca20d2a4dbfd3c72e6cfc4b1b2723b226e7f9031b876a81ee35c6a5edead523 |
ISSN | 0127-5720 |
IngestDate | Fri Jun 28 07:21:12 EDT 2024 Thu May 23 23:19:36 EDT 2024 |
IsPeerReviewed | false |
IsScholarly | true |
Issue | 3 |
Language | English |
LinkModel | OpenURL |
MergedId | FETCHMERGED-LOGICAL-p211t-46ca20d2a4dbfd3c72e6cfc4b1b2723b226e7f9031b876a81ee35c6a5edead523 |
Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
PMID | 25382484 |
PQID | 1622594203 |
PQPubID | 23479 |
PageCount | 5 |
ParticipantIDs | proquest_miscellaneous_1622594203 pubmed_primary_25382484 |
PublicationCentury | 2000 |
PublicationDate | 2014-Sep 20140901 |
PublicationDateYYYYMMDD | 2014-09-01 |
PublicationDate_xml | – month: 09 year: 2014 text: 2014-Sep |
PublicationDecade | 2010 |
PublicationPlace | Malaysia |
PublicationPlace_xml | – name: Malaysia |
PublicationTitle | Tropical biomedicine |
PublicationTitleAlternate | Trop Biomed |
PublicationYear | 2014 |
SSID | ssj0054884 |
Score | 2.0542257 |
Snippet | Human metapneumovirus (HMPV) is a recently discovered cause of viral respiratory infections. We describe clinical and molecular epidemiology of HMPV cases... |
SourceID | proquest pubmed |
SourceType | Aggregation Database Index Database |
StartPage | 562 |
SubjectTerms | Adolescent Age Distribution Child Child, Preschool Cluster Analysis Female Genotype Hospitalization Humans Infant Length of Stay Malaysia - epidemiology Male Metapneumovirus - classification Metapneumovirus - genetics Metapneumovirus - isolation & purification Molecular Epidemiology Molecular Sequence Data Paramyxoviridae Infections - epidemiology Paramyxoviridae Infections - pathology Paramyxoviridae Infections - virology Phylogeny Prevalence Respiratory Tract Infections - epidemiology Respiratory Tract Infections - pathology Respiratory Tract Infections - virology RNA, Viral - genetics Sequence Analysis, DNA Sequence Homology |
Title | Phylogenetic analysis of human metapneumovirus among children with acute respiratory infections in Kuala Lumpur, Malaysia |
URI | https://www.ncbi.nlm.nih.gov/pubmed/25382484 https://search.proquest.com/docview/1622594203 |
Volume | 31 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnZ3da9swEMBF2oexl7Gvbt3WosLeUhdbku3kcWwt6bqUwhLonsLpw3SssY1rD7a_fmfJjtWyQrcXYyRjG_3Ene50dyLkvdChiWWKlipIEQgI40AaNFxhAqgdMpEYG0QzP09mS_H5Mr4cjU69qKWmlkfq91_zSv6HKrYh1zZL9h_Ibl6KDXiPfPGKhPH6IMYXV2huY69xVVeH8iLu5L21qaHMTbMufn6vmpvuYKFb6dtjUG2gQOVtuPfhWS7C_KyBaxh_QehN5XJ7rgG_Av6idlEVpWXtcvlv7dWf2y0B5-ce3Kxf3TQ8HXy08-IK1qDHJ_DD5b4fDzHHs6KwTRfdCzonRSQ2UVgbvyVLgzhloS94eeRNMO5J0dgJaI9gubYIGYpn5oqf3i2T3XdtkS0etbGdn74te5WMVtnEFXnv_qItAd09f79lYVcYi6fkSWca0A-O8zMyMvlz8mjeDegL8svHTXvctMioxU3v4KYWN-1x0xY3tbiph5sOuPGWWtzU4T6kPeyXZHlyvPg4C7qTM4ISDfo6EIkCFmoGQstMc5Uyk6hMCRlJljIucc1t0myKAl2iNoRJZAyPVQKx0ShZYsZ3yHZe5OY1oZkyKPOnXIu29JvWEAmlUDOBVhNcbKpdctCP3wolU7vdBLkpmptVlKCumAoW8l3yyg3sqnQlVFb96L-5t-cteTxMpHdku64as4frv1ruW7Z_ABUVYug |
link.rule.ids | 315,786,790 |
linkProvider | CAB International |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Phylogenetic+analysis+of+human+metapneumovirus+among+children+with+acute+respiratory+infections+in+Kuala+Lumpur%2C+Malaysia&rft.jtitle=Tropical+biomedicine&rft.au=Nor%27e%2C+S+S&rft.au=Sam%2C+I+C&rft.au=Mohamad+Fakri%2C+E+F&rft.au=Hooi%2C+P+S&rft.date=2014-09-01&rft.issn=0127-5720&rft.volume=31&rft.issue=3&rft.spage=562&rft_id=info%3Apmid%2F25382484&rft.externalDocID=25382484 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0127-5720&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0127-5720&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0127-5720&client=summon |