Loss of e-cadherin and retinoblastoma genes in a case of urothelial carcinoma with scrotal metastasis

Cutaneous metastases from urologic cancers are very uncommon, usually represent widespread metastatic disease and are associated with a very poor prognosis. They may occur in 1% of patients with urologic malignancies, most commonly from kidney, followed by bladder and prostate tumors. In this report...

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Bibliographic Details
Published inCanadian journal of urology Vol. 22; no. 2; p. 7755
Main Authors Norberg, Scott M, Oros, Michelle, Manucha, Varsha, Eun, Daniel, Bilusic, Marijo
Format Journal Article
LanguageEnglish
Published Canada 01.04.2015
Subjects
Aged, 80 and over
Cadherins - genetics
Carcinoma, Transitional Cell - drug therapy
Carcinoma, Transitional Cell - genetics
Carcinoma, Transitional Cell - secondary
Drug Therapy
Genes, Retinoblastoma - genetics
Humans
Male
Mutation - genetics
Scrotum
Skin Neoplasms - drug therapy
Skin Neoplasms - genetics
Skin Neoplasms - secondary
Treatment Outcome
Urinary Bladder Neoplasms - drug therapy
Urinary Bladder Neoplasms - genetics
Urinary Bladder Neoplasms - pathology
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Summary:Cutaneous metastases from urologic cancers are very uncommon, usually represent widespread metastatic disease and are associated with a very poor prognosis. They may occur in 1% of patients with urologic malignancies, most commonly from kidney, followed by bladder and prostate tumors. In this report, we describe a case of urothelial carcinoma with metastases to the scrotum treated with platinum based chemotherapy with a durable complete response lasting more than 14 months. Molecular profiling revealed deleterious mutations in e-cadherin and retinoblastoma genes, suggesting their possible role in the pathogenesis of cutaneous metastases. Further studies are needed to validate this observation.
ISSN:1195-9479