Emerging Roles of JmjC Domain-Containing Proteins

• Published in: International review of cell and molecular biology Vol. 319; pp. 165 - 220
• Main Authors: Accari, Sandra L, Fisher, Paul R
• Format: Journal Article
• Language: English
• Published: Netherlands 2015
• Subjects: Animals; Histone-Lysine N-Methyltransferase - metabolism; Histones - metabolism; Humans; Jumonji Domain-Containing Histone Demethylases - metabolism; Jumonji Domain-Containing Histone Demethylases - physiology; Methylation; Plant Proteins - physiology; Protein Processing, Post-Translational; FIH; PAD4; KDM; LSD1; Histone demethylase; JmjC; Jumonji C domain

Jumonji C (JmjC) domain-containing proteins are a diverse superfamily of proteins containing a characteristic, evolutionarily conserved β-barrel structure that normally contains binding sites for Fe(II) and α-ketoglutarate. In the best studied JmjC-domain proteins, the JmjC barrel has a histone deme...